School of Applied Material Sciences, Centre for Applied Chemistry, Central University of Gujarat, Sector-30, Gandhinagar, 382030, India.
Asymmetric synthesis and catalysis laboratory, Department of Chemistry, Central University of Tamil Nadu, Tiruvarur, 610005, India.
Chem Asian J. 2023 Jul 17;18(14):e202300370. doi: 10.1002/asia.202300370. Epub 2023 May 25.
After the emergence of organocatalysis, the field of asymmetric synthesis has reached an exceptional level in this century. Asymmetric aminocatalysis, among other organocatalytic strategies, proceeded through LUMO-lowering iminium ion and HOMO-raising enamine ion activation has appeared as a powerful synthetic approach for realizing potential chiral building blocks from unmodified carbonyl compounds. Consequently, the concept of HOMO-raising activation strategy for a plethora of asymmetric transformations based on enamine, dienamine, and most recently trienamine, tetraenamine, and pentaenamine catalysis has been devised. In this mini-review article, we disclosed the recent progress accomplished in asymmetric aminocatalysis through polyenamine activation strategies for the functionalization of carbonyl compounds, and we covered the reports from 2014 to till date.
自有机催化出现以来，本世纪不对称合成领域已经达到了非凡的水平。不对称氨催化等有机催化策略通过降低最低未占分子轨道（LUMO）的亚胺离子和升高最高占有分子轨道（HOMO）的烯胺离子的激活，已经成为一种从未修饰的羰基化合物中实现潜在手性构建块的有效合成方法。因此，基于烯胺、二烯胺以及最近的三烯胺、四烯胺和五烯胺催化的 HOMO 升高激活策略的概念已经被设计出来，用于实现多种不对称转化。在这篇小型综述文章中，我们披露了通过多烯胺激活策略在羰基化合物的功能化方面取得的最新进展不对称氨催化的研究进展，我们涵盖了从 2014 年至今的报道。
