Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hum Vaccin Immunother. 2023 Dec 31;19(1):2215108. doi: 10.1080/21645515.2023.2215108. Epub 2023 May 21.
Patients with pediatric rheumatic diseases (PRDs) have higher morbidity and mortality associated with infectious diseases. Vaccination is an effective way to prevent infection. This study aimed to understand the vaccination status, vaccination-related attitudes, and adverse reactions in patients with PRDs in one of the largest Pediatric Rheumatic and Immune centers in China. A cross-sectional study using an online questionnaire was conducted among the caregivers of patients with PRDs admitted to the Children's Hospital of Chongqing Medical University. 189 valid questionnaires were collected. The most two common PRDs in this study were juvenile idiopathic arthritis (29.6%) and systemic lupus erythematosus (19.6%). Univariate analysis and multivariate logistic regression were used to identify potential factors associated with vaccination completion among these patients. Univariate analysis suggested that the age of onset, course of the disease, treatment duration, disease duration <1 month, disease duration ≥24 months, treatment duration <1 month, use of biological agents, at least one hospitalization, whether with one-time intravenous human immunoglobulin, caregiver concerns about vaccination before or after illness, and vaccine hesitancy may affect the scheduled vaccination completion by age in patients ( < .05). Multivariate logistic regression analysis showed that the age of onset (OR, 1.013; 95% CI, 1.005-1.022; = .002) and caregiver concerns about vaccination before illness (OR, 0.600; 95% CI, 0.428-0.840; = .003) independently influenced patients' completion of scheduled vaccinations. This study suggests that rheumatic disease and treatment may influence age-appropriate vaccination. Appropriate education for patients and carers may improve vaccination cognition and attitudes.
儿科风湿性疾病（PRD）患者的传染病发病率和死亡率较高。接种疫苗是预防感染的有效方法。本研究旨在了解中国最大的儿科风湿免疫中心之一的 PRD 患者的疫苗接种状况、与疫苗接种相关的态度和不良反应。采用在线问卷对重庆医科大学儿童医院住院 PRD 患儿的照顾者进行了横断面研究。共收集到 189 份有效问卷。本研究中最常见的两种 PRD 是幼年特发性关节炎（29.6%）和系统性红斑狼疮（19.6%）。采用单因素分析和多因素逻辑回归分析确定了这些患者疫苗接种完成情况的潜在相关因素。单因素分析表明，发病年龄、病程、治疗持续时间、病程<1 个月、病程≥24 个月、治疗持续时间<1 个月、使用生物制剂、至少 1 次住院、是否单次静脉注射人免疫球蛋白、患儿在患病前后对疫苗的关注、疫苗犹豫可能影响患者按时接种的年龄（<0.05）。多因素逻辑回归分析显示，发病年龄（OR，1.013；95%CI，1.005-1.022；=0.002）和患儿在患病前对疫苗的关注（OR，0.600；95%CI，0.428-0.840；=0.003）独立影响患者按时完成计划疫苗接种。本研究表明，风湿性疾病和治疗可能会影响适龄疫苗接种。对患者和照顾者进行适当的教育可能会提高疫苗接种认知和态度。
