Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Biotechnol Genet Eng Rev. 2024 Dec;40(4):4434-4445. doi: 10.1080/02648725.2023.2211456. Epub 2023 May 21.
Acute anterior uveitis (AAU) can cause great pain to patients. Th cytokines in peripheral blood are significantly changed in these patients, including serum interleukin-23 (IL-23), interleukin-17 (IL-17), interleukin-4 (IL-4), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) increase. However, the relationship between Th cytokines and recurrence of AAU is still unclear. Ninety-two cases of AAU were enrolled from January 2020 to April 2022 in our hospital (observation group). Levels of peripheral blood Th cytokines were detected, which were compared between acute and remission stages. After 6 months of follow-up, the relationships between Th cytokines in peripheral blood and recurrence in the observation group were analyzed. The prediction of Th cytokines on recurrence was analyzed. (1) The recurrence rate was 25.00%, and there were no statistical differences in the serum IL-23, IL-17, IL-4, IFN-γ, TNF-α and TGF-β 1 levels between patients with bilateral disease and unilateral disease ( < 0.05). (2) The serum IL-23, IL-17, IL-4, IFN-γ, TNF-α and TGF-β 1 levels of recurrence patients were higher than those of non-recurrence ( = 2.971, 5.357, 2.197, 2.766, 4.395, 2.983, < 0.05). (3) The serum IL-23, IL-17, TNF-α levels were risk factors for recurrence (OR = 1.035, 1.210, 1.155, < 0.05). (4) There were positive relationships between serum IL-23, IL-17, IL-4, IFN-γ, TNF-α and TGF-β 1 levels and recurrence ( = 0.317, 0.526, 0.248, 0.304, 0.480, 0.325, < 0.05). .
急性前葡萄膜炎（AAU）可使患者产生剧烈疼痛。这些患者的外周血中的细胞因子明显改变，包括血清白细胞介素-23（IL-23）、白细胞介素-17（IL-17）、白细胞介素-4（IL-4）、干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α）和转化生长因子-β1（TGF-β1）增加。然而，Th 细胞因子与 AAU 复发之间的关系仍不清楚。我院 2020 年 1 月至 2022 年 4 月收治的 92 例 AAU 患者（观察组）纳入研究。检测外周血 Th 细胞因子水平，并比较急性和缓解期的水平。在 6 个月的随访后，分析观察组外周血 Th 细胞因子与复发的关系。分析 Th 细胞因子对复发的预测价值。（1）复发率为 25.00%，双侧病变和单侧病变患者血清 IL-23、IL-17、IL-4、IFN-γ、TNF-α 和 TGF-β1 水平无统计学差异（ < 0.05）。（2）复发患者血清 IL-23、IL-17、IL-4、IFN-γ、TNF-α 和 TGF-β1 水平高于未复发患者（=2.971、5.357、2.197、2.766、4.395、2.983， < 0.05）。（3）血清 IL-23、IL-17、TNF-α 水平是复发的危险因素（OR=1.035、1.210、1.155， < 0.05）。（4）血清 IL-23、IL-17、IL-4、IFN-γ、TNF-α 和 TGF-β1 水平与复发呈正相关（=0.317、0.526、0.248、0.304、0.480、0.325， < 0.05）。
