Small Animal Teaching Hospital, Institute of Veterinary Science, University of Liverpool, Liverpool, UK.
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hanover, Hanover, Germany.
Vet Rec. 2023 Dec 2;193(11):e3053. doi: 10.1002/vetr.3053. Epub 2023 May 21.
Identification of the aetiologic agent in canine discospondylitis is infrequent; and risk factors for a positive bacterial culture have not previously been reported.
Medical records at three institutions were searched to identify clinical features of dogs with discospondylitis diagnosed via radiography or cross-sectional imaging. Inclusion in this retrospective case-control study required culture of one or more samples. Multivariable binary logistic regression identified features associated with a positive culture.
Fifty (42%) of 120 dogs had one or more positive culture results obtained from either urine (28/115), blood (25/78), intervertebral disc aspiration (10/34) or cerebrospinal fluid (1/18). A positive culture was associated with higher bodyweight (p = 0.002, odds ratio [OR] = 1.054, 95% confidence interval [CI]: 1.019-1.089), more sample types cultured (p = 0.037, OR = 1.806, 95% CI: 1.037-3.147) and institution (p = 0.021). The presence of possibly associated preceding events (e.g., surgery), pyrexia, number of disc sites affected and serum C-reactive protein result, among other features, were not statistically significant.
All isolates cultured were included since differentiation of true aetiologic agents from contaminants was not possible without histological confirmation and culture from surgical or postmortem biopsies.
Clinical features typically associated with infection were not identified as risk factors for positive culture in canine discospondylitis. The statistical significance of the institution suggests that standardisation of sampling protocols is necessary.
犬椎间盘炎的病因病原体鉴定并不常见，以前也没有报道过阳性细菌培养的危险因素。
在三个机构的医疗记录中搜索了通过放射学或横断面成像诊断为椎间盘炎的犬的临床特征。本回顾性病例对照研究的纳入标准是需要培养一个或多个样本。多变量二项逻辑回归确定了与阳性培养相关的特征。
120 只犬中，50 只（42%）的尿液（28/115）、血液（25/78）、椎间盘抽吸物（10/34）或脑脊液（1/18）中至少有一个样本的培养结果为阳性。阳性培养与较高的体重（p = 0.002，比值比[OR] = 1.054，95%置信区间[CI]：1.019-1.089）、更多类型的样本培养（p = 0.037，OR = 1.806，95%CI：1.037-3.147）和机构（p = 0.021）有关。其他特征如可能相关的前期事件（如手术）、发热、受影响的椎间盘部位数量和血清 C 反应蛋白结果等，均无统计学意义。
所有培养的分离物均包括在内，因为如果没有组织学确认和手术或尸检活检的培养，就不可能区分真正的病因病原体和污染物。
与感染相关的临床特征未被确定为犬椎间盘炎阳性培养的危险因素。机构的统计学意义表明，有必要对采样方案进行标准化。
