基于 SPSiOL 具有大的二面角的 SPSiPs，一类双膦配体。

SPSiPs, a Class of Diphosphine Ligands Based on SPSiOL with a Large Dihedral Angle.

机构信息

State key laboratory of organometallic chemistry, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai 200032, P. R. China.

Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China.

出版信息

Org Lett. 2023 Jun 2;25(21):3859-3863. doi: 10.1021/acs.orglett.3c01193. Epub 2023 May 22.

DOI:10.1021/acs.orglett.3c01193

PMID:37212832

Abstract

The development and the synthetic applications of a novel class of diphosphine ligands (SPSiPs) based on chiral spirosilabiindane diol (SPSiOL) are presented. Starting from SPSiOL, the diphosphine ligands could be readily prepared in three steps with high efficiency. This novel class of diphosphine ligands features rigid configuration, a large dihedral angle, a large P-M-P angle, and a long P-P distance. The potentials of SPSiPs in asymmetric catalysis have also been preliminarily disclosed.

摘要

介绍了一类新型手性螺双硅茚二酚（SPSiOL）衍生的二膦配体（SPSiPs）的发展和合成应用。以 SPSiOL 为起始原料，通过三步反应以高产率得到二膦配体。该类新型二膦配体具有刚性结构、较大的二面角、较大的 P-M-P 角和较长的 P-P 距离。初步揭示了 SPSiPs 在不对称催化中的应用潜力。