Li Ze-Dong, Ren Fei, Wu Yichen, Li Jian-Jun, Luo Junfei, Wang Peng
Institute of Mass Spectrometry, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, P. R. China.
State Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, CAS 345 Lingling Road, Shanghai, Shanghai 200032, P. R. China.
Org Lett. 2024 Sep 6;26(35):7436-7441. doi: 10.1021/acs.orglett.4c02784. Epub 2024 Aug 26.
Here, we report the development and application of a novel class of spirosilacycle-based diphosphine ligands (SPOSiPs). This type of diphosphine ligand could be readily prepared in two steps with high efficiency starting from enantiopure spirobiphenoxasilin-diol (SPOSiOL). According to the structural analysis of SPOSiP and its PdCl complex, SPOSiPs possess a flexible chiral pocket and feature a rigid configuration, a large dihedral angle, a long P-P distance, and a large P-M-P bite angle in their metal complexes. The potentials of SPOSiPs in asymmetric catalysis have also been preliminarily disclosed.
在此，我们报道了一类新型螺硅环基二膦配体（SPOSiPs）的开发与应用。这类二膦配体可从对映体纯的螺二苯并硅氧烷二醇（SPOSiOL）高效地通过两步轻松制备。根据SPOSiP及其PdCl配合物的结构分析，SPOSiPs具有一个灵活的手性口袋，并且在其金属配合物中具有刚性构型、大的二面角、长的P-P距离和大的P-M-P咬角。SPOSiPs在不对称催化中的潜力也已初步揭示。
