Department of Animal Science, Faculty of Agriculture, Shahrekord University, Shahrekord, 88186 34141, Iran.
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Trop Anim Health Prod. 2023 May 22;55(3):216. doi: 10.1007/s11250-023-03639-8.
In the present study, we evaluated the antihyperlipidemic and antioxidant effects of garlic and dill in comparison with atorvastatin to combat lipogenesis in broiler chickens. A total of 400 1-day-old chicks (Ross 308 strain) were randomly distributed into four experimental diets. Dietary treatments included a control diet, the control diet plus atorvastatin at 20 mg/kg, the control diet plus garlic dry powder (GDP) at 7.5 g/kg, and the control diet plus dill dry powder (DDP) at 7.5 g/kg. Chicks were maintained on experimental diets for 42 days under the recommended environmental conditions set out by the strain management manual. The results showed that weight gain, feed conversion ratio (FCR), and duodenal, jejunal, and ileal dimensions of villi (height, width, and the surface absorptive area) were improved by in-feed atorvastatin, GDP, or DDP when compared to the control (P < 0.05). The inclusion of atorvastatin or phytobiotic products increased circulatory levels of nitric oxide (NO) but decreased circulatory levels of malondialdehyde (MDA), triacylglycerol (TAG), and low-density lipoproteins cholesterol (LDL), with concomitant reductions in the T, R, and S waves amplitudes in the Lead 2 electrocardiogram (ECG) (P < 0.05). Dietary supplements caused an up-regulation of inducible nitric oxide synthase (iNOS), superoxide dismutase 1 (SOD1), and glutathione peroxidase (GPX) but reduced the expression of key hepatic lipogenic enzymes (fatty acid synthase (FAS) and hydroxy-methylglutaryl-CoA reductase (HMGCR) (P < 0.05). In conclusion, feed supplementation with atorvastatin, GDP, or DDP suppressed lipogenesis, enhanced antioxidant response, and improved gut and cardio-pulmonary function in broiler chicks subjected to hypobaric hypoxia.
在本研究中，我们评估了大蒜和莳萝的降血脂和抗氧化作用，并与阿托伐他汀进行了比较，以对抗肉鸡的脂肪生成。将 400 只 1 日龄小鸡（罗斯 308 品系）随机分为四组实验日粮。日粮处理包括对照日粮、对照日粮加 20mg/kg 的阿托伐他汀、对照日粮加 7.5g/kg 的大蒜干粉（GDP）和对照日粮加 7.5g/kg 的莳萝干粉（DDP）。小鸡在推荐的环境条件下，根据品系管理手册的要求，维持实验日粮 42 天。结果表明，与对照组相比，饲料中添加阿托伐他汀、GDP 或 DDP 可提高体重增加、饲料转化率（FCR）以及十二指肠、空肠和回肠绒毛的尺寸（高度、宽度和表面吸收面积）（P<0.05）。添加阿托伐他汀或植物生物制剂可增加循环一氧化氮（NO）水平，但降低循环丙二醛（MDA）、三酰甘油（TAG）和低密度脂蛋白胆固醇（LDL）水平，同时降低心电图（ECG）导联 2 中的 T、R 和 S 波幅度（P<0.05）。日粮补充剂可上调诱导型一氧化氮合酶（iNOS）、超氧化物歧化酶 1（SOD1）和谷胱甘肽过氧化物酶（GPX），但降低关键肝脂肪生成酶（脂肪酸合酶（FAS）和羟甲基戊二酰辅酶 A 还原酶（HMGCR）的表达（P<0.05）。总之，在低压缺氧条件下，饲料中添加阿托伐他汀、GDP 或 DDP 可抑制脂肪生成，增强抗氧化反应，改善肉鸡的肠道和心肺功能。
