Zhen Junhai, Liu Chuan, Liao Fei, Zhang Jixiang, Xie Huabing, Tan Cheng, Dong Weiguo
Department of General Practice, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Front Oncol. 2023 May 5;13:1169369. doi: 10.3389/fonc.2023.1169369. eCollection 2023.
We conducted bibliometric and visualization analyses to evaluate the current research status, hotspots, and trends related to the human microbiota markers in colorectal cancer screening.
The related studies were acquired from the Web of Science Core Collection (WoSCC) database on 5 January 2023. Analyses of the co-occurrence and cooperation relationships between the cited authors, institutions, countries/regions, cited journals, cited articles, and keywords in the studies were carried out using CiteSpace 5.8.R3 software and the Online Analysis platform of Literature Metrology. Additionally, relevant knowledge graphs were drawn to perform visualization analyses; a keywords cluster analysis and a burst analysis were also conducted.
After analyzing 700 relevant articles, this bibliometric analysis found that the annual publications showed an increasing trend from 1992 to 2022. Yu Jun from the Chinese University of Hong Kong had the highest cumulative number of publications, whereas Shanghai Jiao Tong University was the most productive institution. China and the USA have contributed the largest number of studies. The keywords frequency analysis demonstrated that "colorectal cancer," "gut microbiota," "," "risk," and "microbiota" were the most frequent keywords, and the keywords cluster analysis found that the current hotspots were as follows: (a) the precancerous lesions of colorectal cancer (CRC) that need to be screened, such as inflammatory bowel disease (IBD) and advanced adenoma, (b) the gut-derived microbiome for CRC screening, and (c) the early detection of CRC. The burst analysis further showed that the combination of microbiomics with metabolomics might be the future research trend in the field of CRC screening.
The findings of the current bibliometric analysis firstly provide an insight into the current research status, hotspots, and future trends in the field of CRC screening based on the microbiome; the research in this field is becoming more in-depth and diversified. Some human microbiota markers, especially "," are promising biomarkers in CRC screening, and a future hotspot might be the combined analysis of microbiomics and metabolomics for CRC risk screening.
我们进行了文献计量和可视化分析，以评估结直肠癌筛查中人类微生物群标志物的当前研究现状、热点和趋势。
相关研究于2023年1月5日从科学网核心合集（WoSCC）数据库中获取。使用CiteSpace 5.8.R3软件和文献计量在线分析平台，对研究中被引作者、机构、国家/地区、被引期刊、被引文章和关键词之间的共现和合作关系进行分析。此外，绘制了相关知识图谱以进行可视化分析；还进行了关键词聚类分析和突现分析。
在分析了700篇相关文章后，这项文献计量分析发现，从1992年到2022年，年度出版物呈增长趋势。香港中文大学的余俊发表的累计文章数量最多，而上海交通大学是产出最多的机构。中国和美国贡献的研究数量最多。关键词频率分析表明，“结直肠癌”“肠道微生物群”“风险”和“微生物群”是最频繁出现的关键词，关键词聚类分析发现当前热点如下：（a）需要筛查的结直肠癌（CRC）癌前病变，如炎症性肠病（IBD）和高级别腺瘤；（b）用于CRC筛查的肠道微生物组；（c）CRC的早期检测。突现分析进一步表明，微生物组学与代谢组学的结合可能是CRC筛查领域未来的研究趋势。
当前文献计量分析的结果首次揭示了基于微生物组的CRC筛查领域的当前研究现状、热点和未来趋势；该领域的研究正变得更加深入和多样化。一些人类微生物群标志物，尤其是……，是CRC筛查中有前景的生物标志物，未来的一个热点可能是微生物组学和代谢组学联合分析用于CRC风险筛查。
