Chang Yonglong, Ou Qinling, Zhou Xuhui, Liu Jinhui, Zhang Sifang
Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Metabolic Diseases, Changsha, China.
Front Microbiol. 2023 May 5;14:1182006. doi: 10.3389/fmicb.2023.1182006. eCollection 2023.
BACKGROUND: Colorectal cancer (CRC) is a highly prevalent cancer, and the global healthcare system bears a significant burden due to its incidence. Modulating the gut microbiota is a promising approach to enhance the efficacy of CRC treatment and reduce its adverse effects. The causal relationship between specific microorganisms' presence and CRC development has been widely validated. However, few studies have investigated this relationship using bibliometric methods. Therefore, this study analyzed the research hotspots and trends in human gut microbiology and CRC over the last two decades from a bibliometric perspective. The study aims to provide novel insights into basic and clinical research in this field. METHODS: The articles and reviews on gut microbiota in CRC were obtained from the Web of Science Core Collection (WOSCC) on November 2, 2022. CiteSpace and VOSviewer were used to conduct the bibliometric and knowledge-map analysis. RESULTS: A total of 2,707 publications were obtained, with a rapid increase in the number of publications since 2015. The United States and China are the main contributors in this field and have established a network of partnerships in several countries. 414 academic journals have published articles on this topic. The author with the highest number of publications is Jun Yu from the Chinese University of Hong Kong. In addition to "intestinal flora" and "colorectal cancer," high frequency terms in the keyword co-occurrence network analysis included inflammatory bowel disease, , inflammation, long-chain fatty acids, ulcerative colitis, bile acids, and resistant starch. Analysis of keyword trends using burst testing revealed that biomarkers, abnormal crypt foci, bifidobacteria, β-glucuronidase, short-chain fatty acids, bile acids, and DNA methylation are at the forefront of research in this area. CONCLUSION: The findings of this study provide a bibliometric analysis and visualization of the key research areas in gut microbiota and CRC over the past 20 years. The results suggest that the role of gut microbiota in CRC and its underlying mechanisms should be closely monitored, particularly in the areas of biomarkers, metabolic pathways, and DNA methylation, which may emerge as hot topics in this field.
背景：结直肠癌（CRC）是一种高度流行的癌症，其发病率给全球医疗保健系统带来了沉重负担。调节肠道微生物群是提高CRC治疗效果并减少其不良反应的一种有前景的方法。特定微生物的存在与CRC发生之间的因果关系已得到广泛验证。然而，很少有研究使用文献计量学方法来研究这种关系。因此，本研究从文献计量学角度分析了过去二十年中人类肠道微生物学和CRC的研究热点和趋势。该研究旨在为该领域的基础和临床研究提供新的见解。 方法：2022年11月2日从科学引文索引核心合集（WOSCC）获取关于CRC中肠道微生物群的文章和综述。使用CiteSpace和VOSviewer进行文献计量学和知识图谱分析。 结果：共获得2707篇出版物，自2015年以来出版物数量迅速增加。美国和中国是该领域的主要贡献者，并在多个国家建立了合作伙伴网络。414种学术期刊发表了关于该主题的文章。发表文章数量最多的作者是香港中文大学的余俊。在关键词共现网络分析中，除了“肠道菌群”和“结直肠癌”外，高频词汇还包括炎症性肠病、炎症、长链脂肪酸、溃疡性结肠炎、胆汁酸和抗性淀粉。使用突变检测分析关键词趋势表明，生物标志物、异常隐窝病灶、双歧杆菌、β-葡萄糖醛酸酶、短链脂肪酸、胆汁酸和DNA甲基化处于该领域研究的前沿。 结论：本研究结果提供了过去20年中肠道微生物群和CRC关键研究领域的文献计量分析和可视化。结果表明，应密切监测肠道微生物群在CRC中的作用及其潜在机制，特别是在生物标志物、代谢途径和DNA甲基化领域，这些可能会成为该领域的热门话题。
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