Wang Huijie, Zheng Huanwei, Meng Ping, Cao Xu, Liu Jinli, Zhang Teng, Zuo Haiying, Wang Zhichao
Department of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China.
Department of Gastroenterology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, China.
Front Oncol. 2023 May 5;13:1181508. doi: 10.3389/fonc.2023.1181508. eCollection 2023.
The present study was to explore the association between lipoprotein(a) [Lp(a)] and colorectal cancer (CRC) among inpatients. This study included 2822 participants (393 cases vs. 2429 controls) between April 2015 and June 2022. Logistic regression models, smooth curve fitting, and sensitivity analyses were performed to investigate the relationship between Lp(a) and CRC. Compared with the lower Lp(a) quantile 1 (<79.6 mg/L), the adjusted odds ratios (ORs) in quantile 2 (79.6-145.0 mg/L), quantile 3 (146.0-299.0 mg/L), and quantile 4 (≥300.0 mg/L) were 1.41 (95% confidence interval [CI]: 0.95-2.09), 1.54 (95% CI: 1.04-2.27), 1.84 (95% CI: 1.25-2.7), respectively. A linear relationship between lipoprotein(a) and CRC was observed. The finding that Lp(a) has a positive association with CRC supports the "common soil" hypothesis of cardiovascular disease (CVD) and CRC.
本研究旨在探讨住院患者中脂蛋白(a)[Lp(a)]与结直肠癌(CRC)之间的关联。本研究纳入了2015年4月至2022年6月期间的2822名参与者(393例病例与2429例对照)。采用逻辑回归模型、平滑曲线拟合和敏感性分析来研究Lp(a)与CRC之间的关系。与较低的Lp(a)四分位数1(<79.6 mg/L)相比，四分位数2(79.6 - 145.0 mg/L)、四分位数3(146.0 - 299.0 mg/L)和四分位数4(≥300.0 mg/L)的校正比值比(OR)分别为1.41(95%置信区间[CI]: 0.95 - 2.09)、1.54(95% CI: 1.04 - 2.27)、1.84(95% CI: 1.25 - 2.7)。观察到脂蛋白(a)与CRC之间存在线性关系。Lp(a)与CRC呈正相关这一发现支持了心血管疾病(CVD)和CRC的“共同土壤”假说。
