Salle B, Pasquer P, Desebbe C, Rouzioux J M, Barouty B
Helv Paediatr Acta. 1977 Sep;32(3):221-6.
The prevention of neonatal hyperbilirubinemia by phenobarbital is widely used in many countries. However, dose and period of administration vary according to authors, as the dose-effect relation is not known and since little research in pharmacokinetics of phenobarbital has been done so far. In the present study we compared the effect on serum bilirubin of a single injection of 10 mg/kg body weight and of a prolonged administration of 10 mg/kg/day during 3 days in premature and full-term newborn infants. The single injection had the same effect as the prolonged administration, provided it was given within 12 h after birth.
苯巴比妥预防新生儿高胆红素血症在许多国家被广泛应用。然而，由于苯巴比妥的剂量-效应关系尚不明确，且目前关于其药代动力学的研究较少，不同作者所采用的剂量和给药疗程有所不同。在本研究中，我们比较了对早产和足月新生儿单次注射10mg/kg体重以及连续3天每天注射10mg/kg体重对血清胆红素的影响。如果在出生后12小时内给予单次注射，其效果与连续给药相同。
