Zou Jiahuan, Yin Yongyan, Lin Zhenfang, Gong Yulai
School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu,Sichuan, China.
Department of Neurology, Sichuan Bayi Rehabilitation Center (Sichuan Provincial Rehabilitation Hospital), Chengdu, Sichuan, China.
Front Neurosci. 2023 May 5;17:1168773. doi: 10.3389/fnins.2023.1168773. eCollection 2023.
Post-stroke cognitive impairment (PSCI) is a considerable risk factor for developing dementia and reoccurrence of stroke. Understanding the neural mechanisms of cognitive impairment after stroke can facilitate early identification and intervention.
Using functional near-infrared spectroscopy (fNRIS), the present study aimed to examine whether resting-state functional connectivity (FC) of brain networks differs in patients with PSCI, patients with Non-PSCI (NPSCI), and healthy controls (HCs), and whether these features could be used for clinical diagnosis of PSCI.
The present study recruited 16 HCs and 32 post-stroke patients. Based on the diagnostic criteria of PSCI, post-stroke patients were divided to the PSCI or NPSCI group. All participants underwent a 6-min resting-state fNRIS test to measure the hemodynamic responses from regions of interests (ROIs) that were primarily distributed in the prefrontal, somatosensory, and motor cortices.
The results showed that, when compared to the HC group, the PSCI group exhibited significantly decreased interhemispheric FC and intra-right hemispheric FC. ROI analyses showed significantly decreased FC among the regions of somatosensory cortex, dorsolateral prefrontal cortex, and medial prefrontal cortex for the PSCI group than for the HC group. However, no significant difference was found in the FC between the PSCI and the NPSCI groups.
Our findings provide evidence for compromised interhemispheric and intra-right hemispheric functional connectivity in patients with PSCI, suggesting that fNIRS is a promising approach to investigate the effects of stroke on functional connectivity of brain networks.
中风后认知障碍（PSCI）是发生痴呆和中风复发的一个重要风险因素。了解中风后认知障碍的神经机制有助于早期识别和干预。
本研究使用功能近红外光谱（fNRIS），旨在探讨PSCI患者、非PSCI（NPSCI）患者和健康对照者（HCs）的脑网络静息态功能连接（FC）是否存在差异，以及这些特征是否可用于PSCI的临床诊断。
本研究招募了16名健康对照者和32名中风后患者。根据PSCI的诊断标准，将中风后患者分为PSCI组或NPSCI组。所有参与者均接受了6分钟的静息态fNRIS测试，以测量主要分布于前额叶、体感和运动皮层的感兴趣区域（ROIs）的血流动力学反应。
结果显示，与健康对照组相比，PSCI组的半球间FC和右半球内FC显著降低。ROI分析显示，与健康对照组相比，PSCI组体感皮层、背外侧前额叶皮层和内侧前额叶皮层区域之间的FC显著降低。然而，PSCI组和NPSCI组之间的FC没有显著差异。
我们的研究结果为PSCI患者半球间和右半球内功能连接受损提供了证据，表明fNIRS是研究中风对脑网络功能连接影响的一种有前景的方法。
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