Genetic polymorphism of coagulation factor XIII B subunit in the Japanese population: description of three new rare alleles.

Polyacrylamide gel isoelectric focusing (PAGIEF) of neuraminidase-treated EDTA plasma samples followed by electroblotting with enzyme immunoassay was performed to further investigate coagulation factor XIII B subunit (FXIII B) polymorphism. In 435 Japanese subjects PAGIEF patterns of FXIII B were classified into five common and three rare allotypes. This suggested that the FXIII B2 allele existed in the Japanese population in the same manner as in Caucasians. Three new rare allotypes were considered to be controlled by three rare alleles which were designated FXIII B13, FXIII B14, and FXIII B15, respectively. The gene frequencies calculated from 435 Japanese subjects were FXIII B1 = 0.2977, FXIII B2 = 0.0184, FXIII B3 = 0.6805, FXIII B13 = 0.0011, FXIII B14 = 0.0011, and FXIII B15 = 0.0011, respectively.