凝血因子 XIII B 亚基的多态性：FXIIIB*15 在日本人中的进一步出现及血迹中的表型分析
Polymorphism of coagulation factor XIII B subunit: further occurrence of FXIIIB*15 in Japanese and phenotyping in bloodstains.
作者信息
Komatsu N, Kido A, Kimura Y, Oya M, Dobashi Y, Hashimoto K
机构信息
Department of Legal Medicine, Yamanashi Medical University, Japan.
出版信息
Int J Legal Med. 1992;104(6):317-9. doi: 10.1007/BF01369549.
The polymorphism of FXIIIB was investigated in 555 unrelated Japanese individuals using isoelectric focusing and immunoblotting. Five common phenotypes and a rare variant type FXIIIB 15-3 were observed. The allele frequencies were FXIIIB1 = 0.3063, FXIIIB2 = 0.0162, FXIIIB3 = 0.6766 and FXIIIB15 = 0.0009. Phenotyping was also possible from bloodstains stored at 37 degrees C for up to 4 months and from bloodstains stored at room temperature and at 4 degrees C for over 6 months. The FXIIIB system can provide a new powerful genetic marker for the medicolegal grouping of bloodstains.
采用等电聚焦和免疫印迹法，对555名无血缘关系的日本个体的FXIIIB多态性进行了研究。观察到5种常见表型和1种罕见的变异型FXIIIB 15-3。等位基因频率分别为FXIIIB1 = 0.3063、FXIIIB2 = 0.0162、FXIIIB3 = 0.6766和FXIIIB15 = 0.0009。对在37℃保存长达4个月的血迹以及在室温及4℃保存超过6个月的血迹也能够进行表型分析。FXIIIB系统可为血迹的法医学分型提供一种新的强大的遗传标记。
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