中国人群中凝血因子 XIII A 亚基和 B 亚基的基因多态性

Genetic polymorphisms of the A and B subunits of coagulation factor XIII in the Chinese population.

作者信息

Zhang L, Stradmann-Bellinghausen B, Schneider P M, Rittner C

机构信息

Institut für Rechtsmedizin, Johannes-Gutenberg-Universität, Mainz, BRD.

出版信息

Exp Clin Immunogenet. 1993;10(3):137-40.

PMID:8286125

Abstract

Coagulation factor XIIIA and XIIIB polymorphisms in a random population sample from Chengdu in southwest China (n = 121) were studied using isoelectric focusing in polyacrylamide gels followed by immunoblotting with enzyme immunoassay. The allele frequencies were as follows: FXIIIA1 = 0.8719, FXIIIA2 = 0.1240, FXIIIA3 = 0.0041; FXIIIB1 = 0.2727, FXIIIB2 = 0.0165, FXIIIB3 = 0.7107. The distribution of phenotypes of FXIII agrees with the Hardy-Weinberg equilibrium. Comparing these allele frequencies with those reported in other populations, it was found that the allele frequencies of FXIIIA1 and FXIIIB3 in the Chinese population were higher.

摘要

在中国西南部成都的一个随机人群样本（n = 121）中，采用聚丙烯酰胺凝胶等电聚焦法，随后用酶免疫测定法进行免疫印迹，研究了凝血因子ⅩⅢA和ⅩⅢB的多态性。等位基因频率如下：FXⅢA1 = 0.8719，FXⅢA2 = 0.1240，FXⅢA3 = 0.0041；FXⅢB1 = 0.2727，FXⅢB2 = 0.0165，FXⅢB3 = 0.7107。ⅩⅢ因子的表型分布符合哈迪-温伯格平衡。将这些等位基因频率与其他人群中报告的频率进行比较，发现中国人群中FXⅢA1和FXⅢB3的等位基因频率较高。