具有一级吸收的三室开放模型。
A three-compartment open model with first order absorption.
作者信息
Cherruault Y, Sarin V B
出版信息
Int J Biomed Comput. 1986 May;18(3-4):273-81. doi: 10.1016/0020-7101(86)90023-1.
Many drugs confer upon the body the characteristics of a three-compartment model. This paper deals with the estimation of pharmacokinetic parameters of a three-compartment open model, with first order absorption from plasma level data. The central compartment (e.g. plasma) is connected to two other peripheral compartments, and (elimination occurs from only the central compartment. The method of solution involves an optimization method which provides a global minimum of delta, the deviation of plasma concentration from the observed values. The distribution volume of the central compartment and the lag time are also identified. The uniqueness of the absorption rate constant is obtained by the minimum energy principle. The model is tested for different sets of data for the drug Guanfacine (Sandoz laboratories), and the results are compared to those obtained by the generalised least square method.
许多药物赋予身体三室模型的特征。本文探讨了根据血浆水平数据，采用一级吸收方式对三室开放模型的药代动力学参数进行估算。中央室（如血浆）与另外两个外周室相连，且仅从中央室发生消除。求解方法涉及一种优化方法，该方法能使δ（血浆浓度与观测值的偏差）达到全局最小值。同时还能确定中央室的分布容积和滞后时间。吸收速率常数的唯一性通过最小能量原理获得。针对胍法辛（山德士实验室）的不同数据集对该模型进行了测试，并将结果与通过广义最小二乘法获得的结果进行了比较。
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