Primary Health Care, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Department of Psychology, University of Gothenburg, Gothenburg, Sweden.
PLoS One. 2023 May 22;18(5):e0285974. doi: 10.1371/journal.pone.0285974. eCollection 2023.
To assess the hypothesis that low internal health locus of control (IHLC) and psychological distress (PD) are associated with insulin resistance.
In 2002-2005, a random population sample of 2,816 men and women aged 30-74 years participated (76%) in two municipalities in southwestern Sweden. This study included 2,439 participants without previously known diabetes or cardiovascular disease. IHLC was measured by a global scale and PD was measured by the 12-item General Health Questionnaire. Insulin resistance was estimated using HOMA-ir. General linear models were used to estimate differences in HOMA-ir between groups with low IHLC, PD, and both low IHLC and PD, respectively.
Five per cent (n = 138) had both PD and low IHLC, 62 per cent of participants (n = 1509) had neither low IHLC nor PD, 18 per cent (n = 432) had PD, and 15 per cent (n = 360) low IHLC. Participants with both low IHLC and PD had significantly higher HOMA-ir than participants with neither low IHLC nor PD (Δ = 24.8%, 95%CI: 12.0-38.9), also in the fully adjusted model (Δ = 11.8%, 95%CI: 1.5-23.0). Participants with PD had significantly higher HOMA-ir (Δ = 12%, 95%CI: 5.7-18.7), but the significance was lost when BMI was included in the model (Δ = 5.3%, 95%CI:0.0-10.8). Similarly, participants with low IHLC had significantly higher HOMA-ir (Δ = 10.1%, 95%CI: 3.5-17.0) but the significance was lost in the fully adjusted model (Δ = 3.5%, 95%CI: -1.9-9.3).
Internal health locus of control (IHLC) and psychological distress (PD) were associated with insulin resistance. Especially individuals with both PD and low IHLC may need special attention.
评估低内部健康控制源（IHLC）和心理困扰（PD）与胰岛素抵抗相关的假设。
2002-2005 年，在瑞典西南部的两个城市随机抽取了 2816 名年龄在 30-74 岁的男女（76%）参与了这项研究。本研究包括 2439 名无已知糖尿病或心血管疾病的参与者。IHLC 通过一个全球量表进行测量，PD 通过 12 项一般健康问卷进行测量。使用 HOMA-ir 估计胰岛素抵抗。使用一般线性模型分别估计 IHLC 低、PD、IHLC 低和 PD 低的参与者之间 HOMA-ir 的差异。
5%（n=138）的人同时患有 PD 和 IHLC 低，62%的参与者（n=1509）既没有 IHLC 低也没有 PD，18%（n=432）患有 PD，15%（n=360）的人 IHLC 低。同时患有 IHLC 低和 PD 的参与者的 HOMA-ir 显著高于既没有 IHLC 低也没有 PD 的参与者（Δ=24.8%，95%CI：12.0-38.9），在完全调整的模型中也是如此（Δ=11.8%，95%CI：1.5-23.0）。患有 PD 的参与者的 HOMA-ir 显著升高（Δ=12%，95%CI：5.7-18.7），但当 BMI 纳入模型时，其显著性丧失（Δ=5.3%，95%CI：0.0-10.8）。同样，IHLC 低的参与者的 HOMA-ir 显著升高（Δ=10.1%，95%CI：3.5-17.0），但在完全调整的模型中也失去了显著性（Δ=3.5%，95%CI：-1.9-9.3）。
内部健康控制源（IHLC）和心理困扰（PD）与胰岛素抵抗相关。特别是同时患有 PD 和 IHLC 低的个体可能需要特别关注。
