PhD, Departamento de Enfermería, Facultad de Medicina y Ciencias de la Salud, Universidad de Extremadura, 06006, Badajoz, Spain.
PhD, Hospital Universitario de Badajoz, Asociación Oncológica Extremeña, 06006 Badajoz, Spain.
Semin Oncol Nurs. 2023 Aug;39(4):151451. doi: 10.1016/j.soncn.2023.151451. Epub 2023 May 21.
To identify subgroups of psychoneurological symptoms (PNS) and their relationship to different clinical variables in a sample of women with breast cáncer (BC) with different type of treatment, and the possible influence of these on quality of life (QoL), using a factorial principal components analysis.
Observational, cross-sectional, non-probability study (2017-2021) at Badajoz University Hospital (Spain). A total of 239 women with BC receiving treatment were included.
68% of women presented fatigue, 30% depressive symptoms, 37.5% anxiety, 45% insomnia, and 36% cognitive impairment. The average score obtained for pain was 28.9. All the symptoms were related between themselves, and within the cluster of PNS. The factorial analysis showed three subgroups of symptoms, which accounted for 73% of variance: state and trait anxiety (PNS-1), cognitive impairment, pain and fatigue (PNS-2), and sleep disorders (PNS-3). The depressive symptoms were explained equally by PNS-1 and PNS-2. Additionally, two dimensions of QoL were found (functional-physical and cognitive-emotional. These dimensions correlated with the three PNS subgroups found. A relationship was found between chemotherapy treatment and PNS-3, and its negative impact on QoL.
A specific pattern of grouped symptoms in a psychoneurological cluster with different underlying dimensions has been identified which negatively influences QoL of survivors of BC.
It is important to raise awareness among professionals and patients about the existence of a cluster of PNS, the patient's profile, as well as the factors that exacerbate them. This will allow them to be treated more effectively and comprehensively.
在一组接受不同治疗的乳腺癌（BC）女性患者中，通过因子主成分分析，确定精神神经症状（PNS）亚组及其与不同临床变量的关系，并探讨这些亚组对生活质量（QoL）的可能影响。
西班牙巴达霍斯大学医院的观察性、横断面、非概率研究（2017-2021 年）。共纳入 239 名接受治疗的 BC 女性患者。
68%的女性出现疲劳，30%出现抑郁症状，37.5%出现焦虑，45%出现失眠，36%出现认知障碍。疼痛平均得分为 28.9。所有症状之间存在关联，且在 PNS 簇内存在关联。因子分析显示，有三个症状亚组，占方差的 73%：状态和特质焦虑（PNS-1）、认知障碍、疼痛和疲劳（PNS-2）以及睡眠障碍（PNS-3）。抑郁症状同样由 PNS-1 和 PNS-2 解释。此外，还发现了两个 QoL 维度（功能-生理和认知-情感）。这些维度与发现的三个 PNS 亚组相关。发现化疗治疗与 PNS-3 之间存在关系，且其对 QoL 有负面影响。
在乳腺癌幸存者中，存在一个特定的、分组的精神神经簇症状模式，其具有不同的潜在维度，对生活质量有负面影响。
专业人员和患者需要意识到 PNS 簇的存在、患者的特征以及加剧这些症状的因素，这一点非常重要。这将使他们能够更有效地全面治疗这些症状。
