S100 蛋白与心血管疾病。

Medical College, Yangzhou University, Yangzhou, China.

Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225001, Jiangsu, China.

Mol Med. 2023 May 22;29(1):68. doi: 10.1186/s10020-023-00662-1.

Cardiovascular diseases have become a serious threat to human health and life worldwide and have the highest fatality rate. Therefore, the prevention and treatment of cardiovascular diseases have become a focus for public health experts. The expression of S100 proteins is cell- and tissue-specific; they are implicated in cardiovascular, neurodegenerative, and inflammatory diseases and cancer. This review article discusses the progress in the research on the role of S100 protein family members in cardiovascular diseases. Understanding the mechanisms by which these proteins exert their biological function may provide novel concepts for preventing, treating, and predicting cardiovascular diseases.

心血管疾病已成为全球范围内人类健康和生命的严重威胁，其死亡率最高。因此，心血管疾病的预防和治疗已成为公共卫生专家关注的焦点。S100 蛋白的表达具有细胞和组织特异性；它们与心血管疾病、神经退行性疾病、炎症性疾病和癌症有关。本文综述了 S100 蛋白家族成员在心血管疾病中的作用研究进展。了解这些蛋白发挥生物学功能的机制可能为预防、治疗和预测心血管疾病提供新的概念。