Ital J Neurol Sci. 1986 Apr;7(2):195-200. doi: 10.1007/BF02230881.
We present the design of an Italian multicenter case-control study of multiple sclerosis (MS) promoted by the Neuroepidemiology Section of the Italian Society of Neurology (SIN). The principal objective of the study is to verify the existence of an association between MS and migration from the south to the north of Italy and to assess any such association in causal terms (ethnic origin; environmental factors). A second aim is to explore the association between MS, some viral infections suggested as cause(s) of the disease and other variables reported in the literature. The criteria for case and control definition, for their recruitment and the methods of data collection and analysis are described. To date 1593 subjects, of whom 432 have MS, have been included in the study. The first results will become available early in 1986.
我们介绍了由意大利神经病学学会（SIN）神经流行病学部门推动的一项关于多发性硬化症（MS）的意大利多中心病例对照研究的设计。该研究的主要目的是验证MS与从意大利南部向北部迁移之间是否存在关联，并从因果关系方面（种族起源；环境因素）评估任何此类关联。第二个目的是探讨MS、一些被认为是该疾病病因的病毒感染以及文献中报道的其他变量之间的关联。描述了病例和对照的定义标准、招募标准以及数据收集和分析方法。迄今为止，该研究已纳入1593名受试者，其中432人患有MS。首批结果将于1986年初公布。
