La Mantia L, Musicco M, Mantegazza R, Milanese C, Corridori F
Acta Neurol Scand. 1981 Nov;64(5):361-9. doi: 10.1111/j.1600-0404.1981.tb04415.x.
The present study was performed on Milan residents, in order to evaluate the risk of acquiring multiple sclerosis between patients born in Milan and patients born in Southern Italy. For this purpose, 216 consecutive subjects with definite or probable multiple sclerosis, inmates of the Neurological Institute C. Besta (Milan) from 1968-1976, were matched with 216 controls, uniform as regards age, sex, profession and residence, who were hospitalized at the same time for other neurological diseases. Comparing the case/control pairs of the migration, we observed that the North-Centre born had a relative risk of acquiring the disease significantly superior to one (RR = 1.9; P = 0.01) as compared to migrants from the Southern regions of Italy.
本研究以米兰居民为对象，旨在评估出生于米兰的患者与出生于意大利南部的患者患多发性硬化症的风险。为此，从1968年至1976年，对神经学研究所C. 贝斯塔（米兰）收治的216例确诊或疑似患有多发性硬化症的连续病例，与216名年龄、性别、职业和居住地均一致、同时因其他神经系统疾病住院的对照者进行匹配。比较病例/对照对的迁移情况，我们观察到，与来自意大利南部地区的移民相比，出生于意大利北部和中部的人患该病的相对风险显著高于1（RR = 1.9；P = 0.01）。
