Bratisl Lek Listy. 2023;124(7):498-502. doi: 10.4149/BLL_2023_076.
Aging is characterized by appetite loss and cachexia, i.e., factors that contribute to malnutrition. An inflammation marker, neutrophil-to-lymphocyte ratio (NLR), is a significant prognostic predictor of many geriatric syndromes. We aim to determine the association between NLR and malnutrition.
We designed a retrospective study on hospitalized patients in the geriatric unit of a university hospital between January 2019 and January 2021. Demographic data, chronic diseases, history of smoking, length of hospital stay, number of drugs, laboratory and further examinations, and comprehensive geriatric assessment scores were recorded from the hospital data system. The nutritional status of the patients was evaluated using the mini-nutritional assessment (MNA) questionnaire.
Of the 220 patients, 121 (55 %) were female, and the mean age was 77.9 ± 7.3 years. According to the MNA, 60 % (n = 132) were malnourished or at risk of malnutrition. As many as 47.3 % (n = 104) of the patients had depressive symptoms, and 41.4 % (n = 91) were cognitively impaired. The mean age (79.3 ± 7.3), NLR, and GDS scores were significantly higher, and MMSE scores were significantly lower in malnourished patients or in those at risk of malnutrition as compared to patients with normal nutritional status. We showed that NLR (OR: 1.248; 95% CI: 1.066‒1.461; p = 0.006), age (OR: 1.056; 95% CI: 1.005‒1.109; p = 0.031), depressive symptoms (OR: 1.225; 95% CI: 1.096‒1.369; p 4.5, with a sensitivity of 37.9 %, specificity of 85.2 %, negative predictive value of 47.8 %, and positive predictive value of 79.4 %.
NLR, age, depressive symptoms, and cognitive impairment were independently associated risk factors for malnutrition. NLR may be a useful nutritional marker for evaluating the nutritional status of hospitalized geriatric patients (Tab. 4, Fig. 1, Ref. 28). Text in PDF www.elis.sk Keywords: malnutrition, neutrophil-to-lymphocyte ratio, geriatric syndromes, inpatient, older adults.
衰老的特征是食欲下降和恶病质，即导致营养不良的因素。中性粒细胞与淋巴细胞比值（NLR）是许多老年综合征的重要预后预测指标。我们旨在确定 NLR 与营养不良之间的关联。
我们设计了一项回顾性研究，纳入了 2019 年 1 月至 2021 年 1 月期间在大学医院老年病房住院的患者。从医院数据系统中记录了人口统计学数据、慢性疾病、吸烟史、住院时间、药物数量、实验室和其他检查以及全面老年评估评分。使用迷你营养评估（MNA）问卷评估患者的营养状况。
在 220 名患者中，121 名（55%）为女性，平均年龄为 77.9 ± 7.3 岁。根据 MNA，60%（n=132）存在营养不良或营养不良风险。多达 47.3%（n=104）的患者存在抑郁症状，41.4%（n=91）存在认知障碍。与营养状况正常的患者相比，营养不良或存在营养不良风险的患者的平均年龄（79.3 ± 7.3）、NLR 和 GDS 评分更高，而 MMSE 评分更低。我们表明，NLR（OR：1.248；95%CI：1.066-1.461；p=0.006）、年龄（OR：1.056；95%CI：1.005-1.109；p=0.031）、抑郁症状（OR：1.225；95%CI：1.096-1.369；p 4.5，灵敏度为 37.9%，特异性为 85.2%，阴性预测值为 47.8%，阳性预测值为 79.4%。
NLR、年龄、抑郁症状和认知障碍是营养不良的独立危险因素。NLR 可能是评估住院老年患者营养状况的有用营养标志物（表 4，图 1，参考文献 28）。
