Baisiwala Shivani, Ko Myungjun, Zubair Humza, Li Kevin, Vivas Andrew C, Everson Richard, Liau Linda, Bari Ausaf, Patel Kunal S
1Department of Neurosurgery and.
2Brain Tumor Imaging Laboratory, Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
J Neurosurg Case Lessons. 2023 May 22;5(21). doi: 10.3171/CASE232.
Gliosarcoma is a rare and highly malignant cancer of the central nervous system with the ability to metastasize. Secondary gliosarcoma, or the evolution of a spindle cell-predominant tumor after the diagnosis of a World Health Organization grade IV glioblastoma, has also been shown to metastasize. There is little information on metastatic secondary gliosarcoma.
The authors present a series of 7 patients with previously diagnosed glioblastoma presenting with recurrent tumor and associated metastases with repeat tissue diagnosis consistent with gliosarcoma. The authors describe the clinical, imaging, and pathological characteristics in addition to carrying out a systematic review on metastases in secondary gliosarcoma.
The present institutional series and the systematic review of the literature show that metastatic secondary gliosarcoma is a highly aggressive disease with a poor prognosis.
胶质肉瘤是一种罕见的、具有转移能力的中枢神经系统高度恶性肿瘤。继发性胶质肉瘤，即世界卫生组织IV级胶质母细胞瘤诊断后以梭形细胞为主的肿瘤的演变，也已被证明会发生转移。关于转移性继发性胶质肉瘤的信息很少。
作者报告了一系列7例先前诊断为胶质母细胞瘤的患者，这些患者出现复发性肿瘤并伴有转移，重复组织诊断与胶质肉瘤一致。作者除了对继发性胶质肉瘤的转移进行系统综述外，还描述了其临床、影像学和病理特征。
目前的机构系列研究和文献系统综述表明，转移性继发性胶质肉瘤是一种侵袭性很强、预后很差的疾病。
