Briand Marina, Anselmi Elsa, Dagousset Guillaume, Magnier Emmanuel
Université Paris-Saclay, UVSQ, CNRS, UMR 8180 Institut Lavoisier de Versailles, 45 Avenue des Etats-Unis, 78035, Versailles Cedex, France.
Université de Tours, Faculté des Sciences et Techniques, Parc Grandmont, Avenue Monge, 37200, Tours, France.
Chem Rec. 2023 Sep;23(9):e202300114. doi: 10.1002/tcr.202300114. Epub 2023 May 23.
Over the last years, methods devoted to the synthesis of asymmetric molecules bearing a perfluoroalkylated chain have been limited in number. Among them, only a few can be used on a large variety of scaffolds. This microreview aims at summarizing these recent advances in enantioselective perfluoroalkylation (-CF , -CF H, -C F ) and highlights the need for new enantioselective methods to easily synthesize chiral fluorinated molecules which would be useful for the pharmaceutical and agrochemical industries. Some perspectives are also mentioned.
在过去几年中，致力于合成带有全氟烷基链的不对称分子的方法数量有限。其中，只有少数几种可用于多种骨架结构。本微型综述旨在总结对映选择性全氟烷基化（-CF、-CFH、-C₂F）方面的这些最新进展，并强调需要新的对映选择性方法来轻松合成对手性制药和农用化学品行业有用的手性氟化分子。还提及了一些展望。
