School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
J Sci Food Agric. 2023 Oct;103(13):6510-6520. doi: 10.1002/jsfa.12729. Epub 2023 Jun 11.
Ethiprole has been registered to control planthoppers in rice fields for many years in Asia. However, its dissipation and residues in rice under natural field conditions and health hazards are largely unclear. In the present study, a modified QuEChERS (i.e. Quick Easy Cheap Effective Rugged Safe) and high-performance liquid chromatography-tandem mass spectrometry method was established to detect ethiprole and its metabolites, ethiprole amide and ethiprole sulfone, in brown rice, rice husks, and rice straw. The field experiments were implemented in 12 representative provinces of China under Good Agricultural Practices aiming to investigate the fate and terminal residues of ethiprole and its metabolites in rice. Finally, the dietary risk of ethiprole was evaluated.
The average recoveries of these analytes in all matrices were 86.4-99.0% with a repeatability of 0.575-9.38%. The limits of quantification for each compound were 0.01 mg kg . Dissipation of ethiprole followed the single first-order, first + first-order, and first-order multi-compartment kinetic models with a half-life of 2.68-8.99 days in rice husks. The dissipation half-life of ethiprole combining all metabolites was 5.20-16.2 days in rice husks. The terminal residues of ethiprole and its metabolites at preharvest intervals of 21 days were < 0.011, 0.25, and 0.20 mg kg in brown rice, rice husks, and rice straw, respectively. Ethiprole amide was undetectable in all matrices, and the risk quotient of ethiprole was far less than 100%.
Ethiprole rapidly converted to ethiprole sulfone in rice, and ethiprole and ethiprole sulfone mainly remained in rice husks and straws. The dietary risk of ethiprole was acceptable for Chinese consumers. © 2023 Society of Chemical Industry.
乙虫腈多年来在亚洲已被注册用于防治稻田中的稻飞虱。然而，其在自然田间条件下在水稻中的消解和残留以及健康危害在很大程度上仍不清楚。本研究建立了一种改良的 QuEChERS（即快速、简单、廉价、有效、坚固、安全）和高效液相色谱-串联质谱法，用于检测糙米、稻壳和稻草中的乙虫腈及其代谢物乙虫腈酰胺和乙虫腈砜。田间试验在中国 12 个具有良好农业规范的代表性省份实施，旨在研究乙虫腈及其代谢物在水稻中的归趋和最终残留。最后，评估了乙虫腈的膳食风险。
在所有基质中，这些分析物的平均回收率为 86.4-99.0%，重复性为 0.575-9.38%。各化合物的定量限均为 0.01 mg kg。乙虫腈在稻壳中的消解符合单一级、一级+一级和一级多室动力学模型，半衰期为 2.68-8.99 天。乙虫腈结合所有代谢物的消解半衰期在稻壳中为 5.20-16.2 天。21 天收获间隔期内，糙米、稻壳和稻草中乙虫腈及其代谢物的最终残留量分别为<0.011、0.25 和 0.20 mg kg。所有基质中均未检测到乙虫腈酰胺，乙虫腈的风险商数远小于 100%。
乙虫腈在水稻中迅速转化为乙虫腈砜，乙虫腈和乙虫腈砜主要残留在稻壳和稻草中。乙虫腈对中国消费者的膳食风险是可以接受的。© 2023 化学工业协会。
