Mayock D E, LaFramboise W A, Guthrie R D, Standaert T A, Woodrum D E
J Appl Physiol (1985). 1986 Jun;60(6):2015-9. doi: 10.1152/jappl.1986.60.6.2015.
The effects of opiate receptor antagonism by naltrexone hydrochloride on the biphasic hypoxic ventilatory response in the infant Macaca nemestrina have been investigated. Minute ventilation, tidal volume, and respiratory frequency were measured in six animals from timed gestations before and during inhalation of a hypoxic gas mixture. All studies were completed in non-rapid-eye-movement sleep. Arterial blood gases were obtained during each stimulus period. All animals demonstrated the typical biphasic ventilatory response to acute moderate-severe hypoxemia. After the administration of naltrexone hydrochloride to block opiate receptors, the animals still manifested a biphasic hypoxic response that was no different than that noted prior to drug administration. Naltrexone hydrochloride had no effect on room air resting ventilation in any of the animals. Our data suggest that endogenous opiates play no physiological role in the acute ventilatory response to moderate-severe hypoxia in the newborn subhuman primate.
研究了盐酸纳曲酮对婴猴（食蟹猴）双相低氧通气反应的阿片受体拮抗作用。在吸入低氧混合气体之前和期间，对6只来自定时妊娠的动物测量了每分通气量、潮气量和呼吸频率。所有研究均在非快速眼动睡眠状态下完成。在每个刺激期采集动脉血气。所有动物对急性中度至重度低氧血症均表现出典型的双相通气反应。在给予盐酸纳曲酮阻断阿片受体后，动物仍表现出双相低氧反应，与给药前无差异。盐酸纳曲酮对任何动物的室内空气静息通气均无影响。我们的数据表明，内源性阿片类物质在新生非人灵长类动物对中度至重度低氧的急性通气反应中不起生理作用。
