Woodrum D E, Standaert T A, Mayock D E, Guthrie R D
Pediatr Res. 1981 Apr;15(4 Pt 1):367-70. doi: 10.1203/00006450-198104000-00016.
The hypoxic ventilatory response was determined in twelve unanesthetized newborn monkeys, Macaca nemestrina. Measurements of blood gases and ventilation were made during normoxia and hypoxia at the postnatal ages of 2, 7, and 21 days. Data were collected during quiet sleep. The infant monkey demonstrated a definite but transient hyperventilatory response following exposure to a FiO2 of 0.12 or 0.14 on the second day of life. Baseline ventilation increased 15% (Fi02=0.14) and 28% (Fi02=0.12) after 1 minute of hypoxia; p less than 0.05 in both instances. Return to baseline ventilation occurred between 3 and 5 minutes after hypoxic stimulus onset. This biphasic response to hypoxia converted to an adult-like, sustained hyperventilation during the ensuing three weeks of postnatal maturation. Episodes of periodic breathing and/or apnea were noted to occur during the induced hypoxemia. These data demonstrate that the infant subhuman primate has a ventilatory response to hypoxia that is similar to that of the human infant and is an excellent model for the study of the maturation of the respiratory control system.
在12只未麻醉的食蟹猴（Macaca nemestrina）新生猴中测定了低氧通气反应。在出生后第2、7和21天的常氧和低氧期间进行了血气和通气测量。数据是在安静睡眠期间收集的。出生第二天，当暴露于0.12或0.14的吸入氧分数时，幼猴表现出明确但短暂的过度通气反应。低氧1分钟后，基线通气增加了15%（吸入氧分数=0.14）和28%（吸入氧分数=0.12）；两种情况下P均小于0.05。低氧刺激开始后3至5分钟恢复到基线通气。在出生后的三周成熟过程中，这种对低氧的双相反应转变为类似成人的持续过度通气。在诱导的低氧血症期间，观察到周期性呼吸和/或呼吸暂停发作。这些数据表明，幼年灵长类动物对低氧有通气反应，这与人类婴儿相似，是研究呼吸控制系统成熟的优秀模型。
