Division of Hematology-Oncology, Department of Medicine, Center for Health Sciences, University of California, Los Angeles, USA.
HTS Pharma Consulting, San Diego, California, USA.
Clin Infect Dis. 2023 Sep 18;77(6):848-850. doi: 10.1093/cid/ciad309.
Invasive Fusarium infections cause high mortality. Fosmanogepix, a first-in-class antifungal agent, has potent activity against Fusarium. A patient with acute leukemia with invasive fusariosis, probably involving the central nervous system and caused by Fusarium lactis resistant to currently available antifungal agents, was cured of her infection with fosmanogepix. Fosmanogepix was well tolerated.
侵袭性镰刀菌感染导致高死亡率。福司莫尼酯是一种首创的抗真菌药物，对镰刀菌具有强大的活性。一位患有急性白血病合并侵袭性镰刀菌病的患者，可能累及中枢神经系统，由耐现有抗真菌药物的乳镰刀菌引起，她的感染被福司莫尼酯治愈。福司莫尼酯耐受良好。
