Laboratory of Biotechnology and Physiology of Reproduction (LABIREP), Federal University of Ceará, Av. Comandante Maurocélio Rocha Ponte 100, CEP 62041-040, Sobral, CE, Brazil.
Zygote. 2023 Aug;31(4):305-315. doi: 10.1017/S0967199423000254. Epub 2023 May 24.
Preantral to early antral follicles transition is a complex process regulated by endocrine and paracrine factors, as well as by a precise interaction among oocyte, granulosa cells and theca cells. Understanding the mechanisms that regulate this step of folliculogenesis is important to improve culture systems, and opens new perspectives to use oocytes from preantral follicles for assisted reproductive technologies. Therefore, this review aims to discuss the endocrine and paracrine mechanisms that control granulosa cell proliferation and differentiation, formation of the antral cavity, estradiol production, atresia, and follicular fluid production during the transition from preantral to early antral follicles. The strategies that promote growth of preantral follicles are also discussed.
原始卵泡向早腔卵泡过渡是一个由内分泌和旁分泌因素调控的复杂过程，也是卵母细胞、颗粒细胞和膜细胞之间精确相互作用的结果。了解调控卵泡发生这一步骤的机制对于改善培养系统非常重要，并为利用原始卵泡中的卵母细胞进行辅助生殖技术开辟了新的前景。因此，本文旨在讨论控制颗粒细胞增殖和分化、窦腔形成、雌二醇产生、闭锁以及原始卵泡向早腔卵泡过渡过程中卵泡液产生的内分泌和旁分泌机制。还讨论了促进原始卵泡生长的策略。
