Multiple Sclerosis Research Center, Neuroscience Institut, Tehran University of Medical Sciences, Tehran, Iran.
Pediatric Cell and Gene Therapy Research Center, Gene, Cell and Tissue Research Institute , Tehran University of Medical Sciences, Tehran, Iran.
BMC Neurol. 2023 May 23;23(1):201. doi: 10.1186/s12883-023-03239-x.
Autoimmune diseases develop due to self-tolerance failure in recognizing self and non-self-antigens. Several factors play a role in inducing autoimmunity, including genetic and environmental elements. Several studies demonstrated the causative role of viruses; however, some studies showed the preventive effect of viruses in the development of autoimmunity. Neurological autoimmune diseases are classified based on the targets of autoantibodies, which target intracellular or extracellular antigens rather than neurons. Several theories have been hypothesized to explain the role of viruses in the pathogenesis of neuroinflammation and autoimmune diseases. This study reviewed the current data on the immunopathogenesis of viruses in autoimmunity of the nervous system.
自身免疫性疾病是由于识别自身和非自身抗原的自身耐受失败而发展起来的。有几个因素在诱导自身免疫中起作用，包括遗传和环境因素。有几项研究表明了病毒的致病作用；然而，一些研究表明病毒在自身免疫的发展中具有预防作用。神经自身免疫性疾病是根据自身抗体的靶标来分类的，这些靶标针对细胞内或细胞外抗原，而不是神经元。有几种理论假说解释了病毒在神经炎症和自身免疫性疾病发病机制中的作用。本研究综述了目前关于病毒在神经系统自身免疫中的免疫发病机制的相关数据。
Zotero 插件
