Saba J A, Busch H, Wright D, Reddy R
J Biol Chem. 1986 Jul 5;261(19):8750-3.
U4 RNA is one of the abundant small nuclear RNAs implicated in the processing of the 3' -ends of premessenger RNAs (Berget, S. (1984) Nature 309, 179-182). Two potential U4 RNA genes were isolated from a Drosophila genomic DNA library and characterized. These genes, which were from different loci, had transcription and processing signals common to Drosophila U1 and U2 small nuclear RNA genes. One U4 gene locus also contained a downstream 5'-truncated U4 pseudogene. This is the first report in which putative full-length genes for U4 small nuclear RNA were isolated and characterized.
U4 RNA是一种丰富的小核RNA，参与前体信使RNA 3'末端的加工过程（Berget, S. (1984) Nature 309, 179 - 182）。从果蝇基因组DNA文库中分离并鉴定了两个潜在的U4 RNA基因。这些来自不同基因座的基因具有果蝇U1和U2小核RNA基因共有的转录和加工信号。一个U4基因座还包含一个下游5'端截短的U4假基因。这是首次报道分离并鉴定出U4小核RNA的推定全长基因。
