全长人类U4 RNA假基因的核苷酸序列与结构

Nucleotide sequence and organization of full length human U4 RNA pseudogenes.

作者信息

Bark C, Pettersson U

机构信息

Department of Medical Genetics, Uppsala University, Sweden.

出版信息

Gene. 1989 Aug 15;80(2):385-9. doi: 10.1016/0378-1119(89)90304-1.

DOI:10.1016/0378-1119(89)90304-1

PMID:2583518

Abstract

Two loci encoding human U4 RNA, designated U4/7 and U4/14, have been isolated and sequenced. Both are pseudogenes in that their sequences do not match any identified human U4 RNA species perfectly. The U4/7 locus harbours a full-length pseudogene of 144 bp with eight base substitutions in the structural region. This pseudogene might be derived from a hitherto unidentified human U4 RNA gene. The second locus, U4/14, has a complex structure; the structural sequence of a U4 gene has apparently been integrated into an Alu sequence.

摘要

已分离并测序了两个编码人类U4 RNA的基因座，分别命名为U4/7和U4/14。二者均为假基因，因为它们的序列与任何已鉴定的人类U4 RNA种类均不完全匹配。U4/7基因座含有一个144 bp的全长假基因，其结构区域有8个碱基替换。该假基因可能源自一个迄今尚未鉴定的人类U4 RNA基因。第二个基因座U4/14具有复杂的结构；一个U4基因的结构序列显然已整合到一个Alu序列中。