Behar D, Juszynski M, Ben Hur N, Golan J, Eldad A, Tuchman Y, Sterenberg N, Rudensky B
J Biomed Mater Res. 1986 Jul-Aug;20(6):731-8. doi: 10.1002/jbm.820200607.
Omiderm (Omikron Scientific Ltd., Rehovot, Israel), a new synthetic wound covering based on hydrophilized polyurethane, was found to be highly permeable to water. Values in the region of 5000 g/m2 24 h were found for the water permeability of Omiderm in comparison to 1400 and 500 g/m2 24 h for Biobrane (Hall, Woodroof Inc., Santa Ana, CA) and OP site (Smith and Nephew Ltd.), respectively. Permeabilities of antibacterial agents through Omiderm were found to be two to three orders of magnitude greater than those through Biobrane. The in vitro effectiveness of various antibacterial agents in lowering bacterial growth of different bacterial strains were applied to seeded agar plates through Omiderm membrane was investigated. NBH ointment (1% Neomycin, 1% Bacitracin, and 0.5% Hydrocortisone) was found to be the most effective material in inhibiting bacterial growth, except for Pseudomonas aeruginosa where silver sulfadiazine was superior. In in vivo experiments bacterial counts of infected wounds covered with Omiderm and topically treated with NBH were lowered to less than 10(3) organism/g tissue after one day of treatment.
奥米德姆（以色列雷霍沃特的奥米克龙科学有限公司）是一种基于亲水性聚氨酯的新型合成伤口覆盖物，被发现具有高透水性。奥米德姆的透水性在5000克/平方米·24小时左右，相比之下，生物膜（加利福尼亚州圣安娜的霍尔、伍德罗夫公司）和OP贴（施乐辉有限公司）的透水性分别为1400克/平方米·24小时和500克/平方米·24小时。发现抗菌剂通过奥米德姆的渗透率比通过生物膜的渗透率高两到三个数量级。研究了各种抗菌剂通过奥米德姆膜应用于接种琼脂平板上降低不同细菌菌株细菌生长的体外有效性。发现NBH软膏（1%新霉素、1%杆菌肽和0.5%氢化可的松）是抑制细菌生长最有效的材料，但对铜绿假单胞菌而言，磺胺嘧啶银更有效。在体内实验中，用奥米德姆覆盖并局部用NBH治疗的感染伤口在治疗一天后细菌计数降至每克组织少于10³个生物体。
