利用合并样本研究15个插入/缺失基因多态性与精神分裂症风险之间的关联。
Association between 15 insertion/deletion genetic polymorphisms and risk of schizophrenia using pooled samples.
作者信息
Bordbar Maedeh, Saadat Mostafa
机构信息
Department of Biology, College of Sciences, Shiraz University, Shiraz 71467-13565, Iran.
出版信息
EXCLI J. 2023 Feb 28;22:310-314. doi: 10.17179/excli2022-5734. eCollection 2023.
Schizophrenia is a psychiatric syndrome that affects approximately 1 % of the world population and is among the top 10 reasons for disability. In this case-control study, we investigated the association between 15 insertion/deletion (Indel) polymorphisms and schizophrenia risk using pooled samples. In the present case-control study, 361 individuals with schizophrenia and 360 healthy individuals were included in the study. We examined the insertion/deletion polymorphisms in , , , , , , , , , , , , , and genes. Our results revealed that the Del allele of the 14bp Indel polymorphism increased the risk of schizophrenia (OR=1.23, 95 % CI=1.01-1.52, p=0.045) and the Alu allele of the Alu/Alu polymorphism negatively associated with the schizophrenia risk (OR=0.67, 95 % CI=0.54-0.82, p<0.001).
精神分裂症是一种影响全球约1%人口的精神综合征，是导致残疾的十大原因之一。在这项病例对照研究中，我们使用混合样本研究了15种插入/缺失（Indel）多态性与精神分裂症风险之间的关联。在本病例对照研究中，361名精神分裂症患者和360名健康个体被纳入研究。我们检测了、、、、、、、、、、、、和基因中的插入/缺失多态性。我们的结果显示，14bp Indel多态性的缺失等位基因增加了精神分裂症风险（OR=1.23，95%CI=1.01-1.52，p=0.045），而Alu/Alu多态性的Alu等位基因与精神分裂症风险呈负相关（OR=0.67，95%CI=0.54-0.82，p<0.001）。
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