Zhang Xiaolian, Li Shan, Zhang Ying, Lu Yu, Wang Jian, Xu Juanjuan, Li Xi, Qin Xue
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.
Department of Neurosurgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, People's Republic of China.
Hum Immunol. 2014 Dec;75(12):1171-6. doi: 10.1016/j.humimm.2014.10.008. Epub 2014 Oct 19.
We performed a meta-analysis to examine the relationship between the human leukocyte antigen-G (HLA-G) 14 base pairs sequence (14bp) insertion (ins)/deletion (del) polymorphism to systemic lupus erythematosus (SLE). Eligible studies were extracted in PubMed, Embase, Cochrane Library and CNKI (Chinese) up to March 31, 2014. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the strength of the association. Finally, 7 studies with 1864 cases and 2259 controls were involved in this meta-analysis. Overall, the HLA-G 14bp ins/del polymorphism was significantly associated with SLE susceptibility (ins vs. del: OR=1.179, 95%CI=1.037-1.341, P=0.012; ins/ins vs. del/del: OR=1.394, 95%CI=1.153-1.684, P=0.001; ins/del vs. del/del: OR=1.199, 95%CI=1.041-1.382, P=0.012; ins/ins+ins/del vs. del/del: OR=1.252, 95%CI=1.097-1.430, P=0.001). When stratified by ethnicity, significance was found in Asians (ins/ins vs. del/del: OR=1.326, 95%CI=1.001-1.756, P=0.049) and Caucasians (ins/ins vs. del/del: OR=1.454, 95%CI=1.126-1.878, P=0.004; ins/del vs. del/del: OR=1.288, 95%CI=1.051-1.579, P=0.015; ins/ins+ins/del vs. del/del: OR=1.340, 95%CI=1.106-1.623, P=0.003). Our results suggest that the HLA-G 14bp insertion allele might act as an increased risk against SLE. Besides, this is the first meta-analysis to report an association between the HLA-G 14bp ins/del polymorphism and SLE. Larger and well-designed studies are needed to further confirm these findings.
我们进行了一项荟萃分析，以研究人类白细胞抗原-G（HLA-G）14碱基对序列（14bp）插入（ins）/缺失（del）多态性与系统性红斑狼疮（SLE）之间的关系。截至2014年3月31日，在PubMed、Embase、Cochrane图书馆和中国知网（中文）中检索符合条件的研究。通过合并比值比（OR）和95%置信区间（CI）来评估关联强度。最终，7项研究共纳入1864例病例和2259例对照参与了该荟萃分析。总体而言，HLA-G 14bp ins/del多态性与SLE易感性显著相关（ins与del相比：OR=1.179，95%CI=1.037-1.341，P=0.012；ins/ins与del/del相比：OR=1.394，95%CI=1.153-1.684，P=0.001；ins/del与del/del相比：OR=1.199，95%CI=1.041-1.382，P=0.012；ins/ins+ins/del与del/del相比：OR=1.252，95%CI=1.097-1.430，P=0.001）。按种族分层后，在亚洲人群（ins/ins与del/del相比：OR=1.326，95%CI=1.001-1.756，P=0.049）和白种人群（ins/ins与del/del相比：OR=1.454，95%CI=1.126-1.878，P=0.004；ins/del与del/del相比：OR=1.288，95%CI=1.051-1.579，P=0.
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