Colas Kelly, Vyas Kavita, Sheth Dipa K
Department of Allergy and Immunology, University of Washington, Seattle.
Department of Pulmonary and Critical Care, Washington DC Veterans Affairs Medical Center.
Fed Pract. 2023 Jan;40(1):16-21. doi: 10.12788/fp.0352. Epub 2023 Jan 16.
The use of biologic agents for severe asthma has transformed management, decreasing asthma exacerbations, improving lung function, reducing corticosteroid use, and decreasing hospitalizations. However, numerous financial and logistic barriers have complicated the implementation of biologic agents, including long wait times to see specialists and insurance coverage.
A retrospective chart review was performed for 15 patients enrolled in this severe allergy clinic at the Washington DC Veterans Affairs Medical Center over 30 months. Outcomes examined included emergency department visits, hospitalizations, intensive care unit (ICU) stays, forced expiratory volume (FEV), and steroid use. The average use of steroids decreased from 4.2 to 0.6 tapers per year following the initiation of biologics. There was an average 10% improvement in FEV after starting a biologic. Thirteen percent of patients (n = 2) had an emergency department visit for an asthma exacerbation since starting a biologic agent, 0.6% of patients (n = 1) had a hospital admission for an asthma exacerbation, and no patients had an ICU stay.
Biologic agents have significantly improved outcomes for patients with severe asthma. The model of a combined allergy/pulmonology clinic can be particularly efficacious in the treatment of severe asthma, as it reduces the need for multiple appointments with different specialties, reduces wait time before starting a biologic agent, and offers the perspective of 2 specialists.
生物制剂用于重度哮喘已改变了治疗方式,减少了哮喘发作,改善了肺功能,减少了皮质类固醇的使用,并降低了住院率。然而,众多财务和后勤障碍使生物制剂的应用变得复杂,包括等待看专科医生的时间长和保险覆盖问题。
对华盛顿特区退伍军人事务医疗中心该重症过敏诊所30个月内登记的15例患者进行了回顾性病历审查。检查的结果包括急诊就诊、住院、重症监护病房(ICU)住院时间、用力呼气量(FEV)和类固醇使用情况。开始使用生物制剂后,类固醇的年平均使用量从4.2次减量降至0.6次减量。开始使用生物制剂后,FEV平均改善了10%。自开始使用生物制剂以来,13%的患者(n = 2)因哮喘发作到急诊就诊,0.6%的患者(n = 1)因哮喘发作住院,没有患者入住ICU。
生物制剂显著改善了重度哮喘患者的治疗效果。过敏/肺病联合诊所模式在重度哮喘治疗中可能特别有效,因为它减少了与不同专科进行多次预约的需求,缩短了开始使用生物制剂前的等待时间,并提供了两位专科医生的专业意见。