Saadati Nayereh, Miri Maryam
Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Caspian J Intern Med. 2023 Spring;14(2):231-236. doi: 10.22088/cjim.14.2.231.
Lupus nephritis (LN) is a debilitating complication of systemic lupus erythematosus (SLE). Renal biopsy is the gold standard for evaluating LN. Serum C4d is a potential non-invasive method for evaluating LN. The purpose of this study was to evaluate the value of C4d in the assessment of LN.
This cross-sectional study was conducted on patients with LN who were referred to a tertiary hospital in Mashhad, Iran. Subjects were divided into four groups including LN, SLE without renal involvement, chronic kidney disease (CKD) and healthy controls. Serum C4d. creatinine, and glomerular filtration rate (GFR) were assessed for all subjects.
Forty-three subjects (11, 25.6% healthy controls, 9, 20.9% SLE patients, 13, 30.2% LN and 10, 23.3% CKD patients) participated in this study. CKD group were significantly older than other groups (p>0.05). There was a significant difference in gender distribution between groups (p<0.001). Median serum C4d were 0.6 in healthy controls and CKD group and 0.3 in SLE and LN groups. There was no significant difference in serum C4d between groups (p=0.503).
The findings of this study indicated that serum C4d might not be a promising marker in the assessment of LN. These findings should be documented by further multicenter studies.
狼疮性肾炎（LN）是系统性红斑狼疮（SLE）的一种使人衰弱的并发症。肾活检是评估LN的金标准。血清C4d是评估LN的一种潜在非侵入性方法。本研究的目的是评估C4d在LN评估中的价值。
本横断面研究针对转诊至伊朗马什哈德一家三级医院的LN患者进行。受试者分为四组，包括LN组、无肾脏受累的SLE组、慢性肾脏病（CKD）组和健康对照组。对所有受试者评估血清C4d、肌酐和肾小球滤过率（GFR）。
43名受试者（11名，25.6%为健康对照组；9名，20.9%为SLE患者；13名，30.2%为LN患者；10名，23.3%为CKD患者）参与了本研究。CKD组比其他组显著年长（p>0.05）。各组间性别分布存在显著差异（p<0.001）。健康对照组和CKD组的血清C4d中位数为0.6，SLE组和LN组为0.3。各组间血清C4d无显著差异（p=0.503）。
本研究结果表明，血清C4d在LN评估中可能不是一个有前景的标志物。这些结果应由进一步的多中心研究加以证实。
