Ebrahimzadeh Manijeh, Haghshenas Khadijeh, Kashifard Mehrdad, Shokri-Shirvani Javad
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
Caspian J Intern Med. 2023 Spring;14(2):179-184. doi: 10.22088/cjim.14.2.179.
infection is the most common cause of peptic ulcer disease. However, the prevalence rates of non-helicobacter pylori idiopathic peptic ulcers have increased over the past few years. This study aims to compare the characteristics of -positive with idiopathic duodenal ulcers.
A cross-sectional cohort study was conducted on 950 patients which were excluded from the analysis process duo to the concomitant presence of gastric ulcer, malignancy, Zollinger Ellison syndrome, Crohn's disease, esophageal varices, history of taking anti-Helicobacter pylori therapy, and history of taking NSAID or aspirin. Eventually, 647 subjects were enrolled for the analysis process. In this case, these subjects were divided into two groups: (I) -positive ulcer group and (II) -negative and non-NSAID (idiopathic) ulcer group.
The findings showed that 417 patients (64.5%) had duodenal ulcers induced by , and 111 patients (17.1%) had -negative and non-NSAID ulcers. The mean ages of patients in -positive and idiopathic ulcer groups were 39±15 and 42±17, respectively. In this case, 33 patients (29.7%) with idiopathic ulcers and 56 patients (25.1%) with -positive ulcers had upper gastrointestinal bleeding. Also, 22 patients (21%) with idiopathic ulcers and 31 patients (16.5%) with -positive ulcers had multiple duodenal ulcers.
The present study demonstrated that the idiopathic ulcers included 17.1% of duodenal ulcers. Also, it was concluded that patients with idiopathic ulcers were predominantly male with an age range older than the other group. In addition, patients in this group had more ulcers.
感染是消化性溃疡疾病最常见的病因。然而，在过去几年中，非幽门螺杆菌感染性特发性消化性溃疡的患病率有所上升。本研究旨在比较幽门螺杆菌阳性与特发性十二指肠溃疡的特征。
对950例患者进行了一项横断面队列研究，这些患者因同时存在胃溃疡、恶性肿瘤、卓-艾综合征、克罗恩病、食管静脉曲张、接受过抗幽门螺杆菌治疗以及服用非甾体抗炎药或阿司匹林的病史而被排除在分析过程之外。最终，647名受试者被纳入分析过程。在这种情况下，这些受试者被分为两组：（I）幽门螺杆菌阳性溃疡组和（II）幽门螺杆菌阴性且非非甾体抗炎药（特发性）溃疡组。
研究结果显示，417例患者（64.5%）患有幽门螺杆菌诱发的十二指肠溃疡，111例患者（17.1%）患有幽门螺杆菌阴性且非非甾体抗炎药溃疡。幽门螺杆菌阳性组和特发性溃疡组患者的平均年龄分别为39±15岁和42±17岁。在这种情况下，33例（29.7%）特发性溃疡患者和56例（25.1%）幽门螺杆菌阳性溃疡患者发生上消化道出血。此外，22例（21%）特发性溃疡患者和31例（16.5%）幽门螺杆菌阳性溃疡患者患有多发性十二指肠溃疡。
本研究表明，特发性溃疡占十二指肠溃疡的17.1%。此外，得出的结论是，特发性溃疡患者以男性为主，年龄范围比另一组大。此外，该组患者溃疡更多。
