Sayehmiri Kourosh, Abangah Ghobad, Kalvandi Gholamreza, Tavan Hamed, Aazami Sanaz
Department of Community Medicine, Faculty of Medicine, Psychosocial Injuries Research Center, Ilam, Iran.
Department of Gastroenterology, Faculty of Medicine, Ilam, Iran.
J Res Med Sci. 2018 Jan 29;23:8. doi: 10.4103/jrms.JRMS_1035_16. eCollection 2018.
Peptic ulcer is a prevalent problem and symptoms include epigastria pain and heartburn. This study aimed at investigating the prevalence and causes of peptic ulcers in Iran using systematic review and meta-analysis.
Eleven Iranian papers published from 2002 to 2016 are selected using valid keywords in the SID, Goggle scholar, PubMed and Elsevier databases. Results of studies pooled using random effects model in meta-analysis. The heterogeneity of the sample was checked using Q test and index.
Total sample size in this study consist of 1335 individuals with peptic ulcer (121 samples per article). The prevalence of peptic ulcers was estimated 34% (95% CI= 0.25 - 0.43). The prevalence of peptic ulcers was 30% and 60% in woman and man respectively. The highest environmental factor (cigarette) has been addressed in 30% (95% CI= 0.23-0.37) of patients. The prevalence of Helicobacter pylori was estimated in 62% (95% CI= 0.49-0.75) of patients.
The results of this study show that prevalence of peptic ulcers in Iran (34%) is higher that worldwide rate (6% to 15%). There was an increasing trend in the prevalence of peptic ulcer over a decade from 2002 to 2016.
消化性溃疡是一个普遍存在的问题，症状包括上腹部疼痛和烧心。本研究旨在通过系统评价和荟萃分析调查伊朗消化性溃疡的患病率及病因。
在伊朗科学信息数据库（SID）、谷歌学术、PubMed和爱思唯尔数据库中使用有效关键词筛选出2002年至2016年发表的11篇伊朗论文。研究结果在荟萃分析中采用随机效应模型进行汇总。使用Q检验和I²指数检查样本的异质性。
本研究的总样本量为1335名消化性溃疡患者（每篇文章121个样本）。消化性溃疡的患病率估计为34%（95%置信区间=0.25 - 0.43）。女性和男性消化性溃疡的患病率分别为30%和60%。30%（95%置信区间=0.23 - 0.37）的患者提到了最高的环境因素（吸烟）。幽门螺杆菌的患病率估计为62%（95%置信区间=0.49 - 0.75）。
本研究结果表明，伊朗消化性溃疡的患病率（34%）高于全球患病率（6%至15%）。从2002年到2016年的十年间，消化性溃疡的患病率呈上升趋势。
