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Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway.

作者信息

Hou Jia-Yi, Gao Li-Juan, Shen Jing, Zhou Lan, Shi Jian-Yun, Sun Teng, Hao Shu-Lan, Wang De-Ping, Cao Ji-Min

机构信息

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China.

Department of Clinical Laboratory, Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan, Shanxi 030012, China.

出版信息

Genes Dis. 2022 Mar 31;10(2):332-335. doi: 10.1016/j.gendis.2022.02.018. eCollection 2023 Mar.

DOI:10.1016/j.gendis.2022.02.018
PMID:37223496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10201592/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1276/10201592/f391efbd32ac/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1276/10201592/f391efbd32ac/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1276/10201592/f391efbd32ac/gr1.jpg

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Regulatory Mechanism of Protein Crotonylation and Its Relationship with Cancer.

本文引用的文献

1
Cancer treatment and survivorship statistics, 2019.2019 年癌症治疗与生存统计
CA Cancer J Clin. 2019 Sep;69(5):363-385. doi: 10.3322/caac.21565. Epub 2019 Jun 11.
2
Global profiling of crotonylation on non-histone proteins.非组蛋白上巴豆酰化的全基因组分析。
Cell Res. 2017 Jul;27(7):946-949. doi: 10.1038/cr.2017.60. Epub 2017 Apr 21.
3
Signal transduction by focal adhesion kinase in cancer.粘着斑激酶在癌症中的信号转导
蛋白巴豆酰化的调控机制及其与癌症的关系。
Cells. 2024 Nov 2;13(21):1812. doi: 10.3390/cells13211812.
4
PTBP1 crotonylation promotes colorectal cancer progression through alternative splicing-mediated upregulation of the PKM2 gene.PTBP1 琥珀酰化通过选择性剪接介导的 PKM2 基因上调促进结直肠癌的进展。
J Transl Med. 2024 Nov 4;22(1):995. doi: 10.1186/s12967-024-05793-5.
5
Therapeutic, Clinicopathological, and Molecular Correlates of Expression in Gastrointestinal Cancers.胃肠道癌症中表达的治疗、临床病理及分子相关性
Pharmaceuticals (Basel). 2024 Sep 25;17(10):1263. doi: 10.3390/ph17101263.
Cancer Metastasis Rev. 2009 Jun;28(1-2):35-49. doi: 10.1007/s10555-008-9165-4.
4
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.蛋白激酶A催化亚基与调节亚基（RIα）复合物的晶体结构
Science. 2005 Feb 4;307(5710):690-6. doi: 10.1126/science.1104607.
5
Minireview: PRKAR1A: normal and abnormal functions.综述：PRKAR1A：正常与异常功能
Endocrinology. 2004 Dec;145(12):5452-8. doi: 10.1210/en.2004-0900. Epub 2004 Aug 26.