El Iskandarani Sarah, Khasho Maya, Merashli Mira
Memorial Sloan Kettering Cancer Center, Integrative Medicine Service, New York City, New York, USA.
Tishreen University, Faculty of Medicine, Latakia, Syria.
Mediterr J Rheumatol. 2023 Mar 31;34(1):78-85. doi: 10.31138/mjr.34.1.78. eCollection 2023 Mar.
Eosinophilic fasciitis (EF) is a rare connective-tissue disorder that is characterised by subacute onset of erythema, oedema, and induration of the skin and soft tissues of the limbs and trunk. Although several triggers have been hypothesised to be associated with EF, the aetiology of eosinophilic fasciitis (EF) is still unclear, and several treatment regimens have been proposed to treat this disease. In this article, we report a case of a 72-year-old gentleman with multiple comorbidities who presented to the clinic for diffuse skin thickening present on his forearms, thighs, legs bilaterally, and over the pelvis. The patient was diagnosed with EF and failed multiple treatment regimens including prednisone, methotrexate, rituximab, but finally responded and was maintained on tocilizumab. In this article, we will review the current understanding of EF, diagnostic approach, popular treatments and review other cases of EF in which tocilizumab was used.
嗜酸性筋膜炎（EF）是一种罕见的结缔组织疾病，其特征为四肢和躯干皮肤及软组织出现亚急性红斑、水肿和硬结。尽管已有多种诱因被认为与嗜酸性筋膜炎有关，但嗜酸性筋膜炎的病因仍不明确，并且已经提出了多种治疗方案来治疗这种疾病。在本文中，我们报告了一例72岁的男性患者，他患有多种合并症，因双侧前臂、大腿、小腿及骨盆出现弥漫性皮肤增厚而前来就诊。该患者被诊断为嗜酸性筋膜炎，接受了包括泼尼松、甲氨蝶呤、利妥昔单抗在内的多种治疗方案均无效，但最终对托珠单抗产生反应并继续使用托珠单抗进行维持治疗。在本文中，我们将回顾目前对嗜酸性筋膜炎的认识、诊断方法、常用治疗方法，并回顾其他使用托珠单抗治疗嗜酸性筋膜炎的病例。
