Schwedt Inge, Wang Mengyi, Gibhardt Johannes, Commichau Fabian M
FG Microbiology, Molecular Microbiology, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
Microlife. 2023 Jan 28;4:uqad005. doi: 10.1093/femsml/uqad005. eCollection 2023.
Cyclic di-AMP is an emerging second messenger that is synthesized by many archaea and bacteria, including the Gram-positive pathogenic bacterium played a crucial role in elucidating the essential function of c-di-AMP, thereby becoming a model system for studying c-di-AMP metabolism and the influence of the nucleotide on cell physiology. c-di-AMP is synthesized by a diadenylate cyclase and degraded by two phosphodiesterases. To date, eight c-di-AMP receptor proteins have been identified in , including one that indirectly controls the uptake of osmotically active peptides and thus the cellular turgor. The functions of two c-di-AMP-receptor proteins still need to be elucidated. Here, we provide an overview of c-di-AMP signalling in and highlight the main differences compared to the other established model systems in which c-di-AMP metabolism is investigated. Moreover, we discuss the most important questions that need to be answered to fully understand the role of c-di-AMP in osmoregulation and in the control of central metabolism.
环二腺苷酸（c-di-AMP）是一种新兴的第二信使，由许多古生菌和细菌合成，包括革兰氏阳性病原菌。它在阐明c-di-AMP的基本功能中起着关键作用，从而成为研究c-di-AMP代谢及其对细胞生理学影响的模型系统。c-di-AMP由二腺苷酸环化酶合成，并由两种磷酸二酯酶降解。迄今为止，已在[具体物种名称未给出]中鉴定出8种c-di-AMP受体蛋白，其中一种间接控制渗透活性肽的摄取，进而控制细胞膨压。另外两种c-di-AMP受体蛋白的功能仍有待阐明。在此，我们概述了[具体物种名称未给出]中的c-di-AMP信号传导，并强调了与其他研究c-di-AMP代谢的既定模型系统相比的主要差异。此外，我们讨论了要全面理解c-di-AMP在渗透调节和中心代谢控制中的作用需要回答的最重要问题。
