Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Cell Mol Biol (Noisy-le-grand). 2023 Feb 28;69(2):133-137. doi: 10.14715/cmb/2023.69.2.22.
This study was to investigate the effect of microecological regulators combined with enteral nutrition on immune and coagulation function in patients with a chronic critical illness. For this purpose, 78 patients with chronic critical illness in our hospital from January 2020 to January 2022 were divided into study and control groups according to a simple random number table, with 39 cases in each group. The control group was given enteral nutrition support, and the study group was given a microecological regulator. The variables of the study were the intervention effects [albumin (ALB), prealbumin (PA), serum total protein (TP)], immune function (CD3+, CD4+, CD4+/CD8+), coagulation function [platelet count (PLT), Fibrinogen (FIB), prothrombin time (PT) and the incidence of complications. Results showed that Before the intervention, ALB (30.69 ± 3.66) G/L, PA (132.91 ± 18.04) mg/L, TP (55.65 ± 5.42) G/L in the study group and ALB (31.78 ± 4.24) TP (57.01 ± 5.13) G/L had no significant difference (P>0.05). After the intervention, the levels of ALB, PA and TP in the two groups were higher than those before the intervention. ALB (38.91 ± 3.54) G/L, PA (204.24 ± 28.80) mg/L and TP (69.75 ± 7.48) G/L in the study group were higher than those in the control group (ALB 34.83 ± 3.82) TP (62.70 ± 6.33) g/L (P<0.05). There was no significant difference between CD4+/CD8+ (1.31 ± 0.39) (P>0.05). After the intervention, the levels of CD3+, CD4+, CD4 and CD8 in the two groups were higher than those before the intervention. CD3+, CD4+ and CD4+/CD8+ were higher than that of the control group. in the study group PLT (226.57 ± 41.15) × 109/L, FIB (3.58 ± 1.09) G/L, PT (9.41 ± 0.82) s were recoeded. There was no significant difference between FIB (3.71 ± 1.13) G/L and PT (9.24 ± 0.77) s (P>0.05). After the intervention, PLT and FIB decreased and PT increased in both groups. PLT (177.15 ± 12.51) × 109/L and FIB (2.57 ± 0.39) G/L in the study group were lower than PLT (198.54 ± 10.77) × 109/L and FIB (3.04 ± 0.54) PT (15.79 ± 1.21) s was higher than PT (13.13 ± 1.33) s in the control group (P<0.05). The incidence of complications in the study group (5.13%) was lower than that in the control group (20.51%) (P<0.05). The conclusion was that the intervention effect of microecological regulators combined with enteral nutrition on patients with chronic critical illness is significant, which can improve their nutritional status and immune function, improve coagulation function, and reduce the incidence of complications.
本研究旨在探讨微生态调节剂联合肠内营养对慢性危重症患者免疫和凝血功能的影响。为此，将我院 2020 年 1 月至 2022 年 1 月收治的 78 例慢性危重症患者按照简单随机数字表法分为研究组和对照组，每组 39 例。对照组给予肠内营养支持，研究组给予微生态调节剂。研究的变量包括干预效果[白蛋白（ALB）、前白蛋白（PA）、血清总蛋白（TP）]、免疫功能（CD3+、CD4+、CD4+/CD8+）、凝血功能[血小板计数（PLT）、纤维蛋白原（FIB）、凝血酶原时间（PT）]和并发症发生率。结果显示，干预前，研究组和对照组的 ALB（30.69±3.66）g/L、PA（132.91±18.04）mg/L、TP（55.65±5.42）g/L 差异无统计学意义（P＞0.05）。干预后，两组 ALB、PA 和 TP 水平均高于干预前，研究组 ALB（38.91±3.54）g/L、PA（204.24±28.80）mg/L、TP（69.75±7.48）g/L 高于对照组 ALB（34.83±3.82）g/L、TP（62.70±6.33）g/L（P＜0.05）。CD4+/CD8+（1.31±0.39）差异无统计学意义（P＞0.05）。干预后，两组 CD3+、CD4+、CD4+/CD8+水平均高于干预前，且研究组高于对照组。PLT（226.57±41.15）×109/L、FIB（3.58±1.09）g/L、PT（9.41±0.82）s 差异无统计学意义（P＞0.05）。干预后，两组 FIB（3.71±1.13）g/L 和 PT（9.24±0.77）s 差异无统计学意义（P＞0.05）。干预后，两组 PLT 和 FIB 降低，PT 升高，研究组 PLT（177.15±12.51）×109/L、FIB（2.57±0.39）g/L 低于对照组 PLT（198.54±10.77）×109/L、FIB（3.04±0.54）g/L，PT（15.79±1.21）s 高于对照组 PT（13.13±1.33）s（P＜0.05）。研究组并发症发生率（5.13%）低于对照组（20.51%）（P＜0.05）。结论，微生态调节剂联合肠内营养对慢性危重症患者的干预效果显著，能改善患者的营养状态和免疫功能，改善凝血功能，降低并发症发生率。
