芪黄汤联合肠内营养对胃癌术后营养及免疫功能的影响
Effect of Qihuang Decoction Combined with Enteral Nutrition on Postoperative Gastric Cancer of Nutrition and Immune Function.
作者信息
Yu Qing-Sheng, Zheng Zhou, Peng Hui, Shen Yi, Liu Ju-da, Zhou Fu-Hai
机构信息
Department of General Surgery, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Institute of Chinese Medicine Surgery, Anhui University of Traditional Chinese Medicine, Hefei, China.
出版信息
Evid Based Complement Alternat Med. 2020 Feb 29;2020:1795107. doi: 10.1155/2020/1795107. eCollection 2020.
OBJECTIVE
Early nutritional support in patients with gastric cancer can improve their nutritional status, but the impact on immune function has not been confirmed. This study aimed to analyze the effects of Qihuang decoction combined with enteral nutrition on nutrition and the immune function of postoperative gastric cancer.
METHODS
120 patients with postoperative gastric cancer in the study group and 117 in the control group were selected as the study subjects from our hospital at random. Indications of nutrition and immune and the rates of complications were compared the day before surgery and 1, 3, 7, and 14 days after surgery.
RESULTS
Indications of nutrition except hemoglobin (HB) in the study group were significantly higher than those before operation and the albumin (ALB) and prealbumin (TP) were significantly increased 7 and 14 days after surgery ( < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 and < 0.001 versus < 0.001 and < 0.001) and the protein (PA) 3, 7, and 14 days after surgery (=0.011, =0.002, and =0.022) in the study group compared to those in the control group. Cellular and humoral immunity indications in the study group are significantly higher than those before operation compared to those in the control group, and the CD3, CD4, and CD4/CD8 were significantly increased 7 and 14 days after surgery (=0.027 and < 0.001 versus =0.008 and < 0.001 versus =0.010 and < 0.001) and IgA, IgG, and IgM 3, 7, and 14 days after surgery in the study group ( < 0.001, < 0.001, and < 0.001 versus < 0.001, < 0.002, and < 0.001 versus < 0.001, < 0.001, and < 0.001). The complications such as abdominal, lung, wound, and urinary infection were also significantly decreased ( =0.017; < 0.001 and < 0.001 versus < 0.001 and < 0.001) and the protein (PA) 3, 7, and 14 days after surgery (=0.011, =0.002, and =0.022) in the study group compared to those in the control group. Cellular and humoral immunity indications in the study group are significantly higher than those before operation compared to those in the control group, and the CD3, CD4, and CD4/CD8 were significantly increased 7 and 14 days after surgery (=0.027 and < 0.001 versus =0.008 and < 0.001 versus =0.010 and < 0.001) and IgA, IgG, and IgM 3, 7, and 14 days after surgery in the study group ( < 0.001, < 0.001, and < 0.001 versus < 0.001, < 0.002, and < 0.001 versus < 0.001, < 0.001, and < 0.001). The complications such as abdominal, lung, wound, and urinary infection were also significantly decreased ( =0.017; < 0.001 and < 0.001 versus < 0.001 and < 0.001) and the protein (PA) 3, 7, and 14 days after surgery (=0.011, =0.002, and =0.022) in the study group compared to those in the control group. Cellular and humoral immunity indications in the study group are significantly higher than those before operation compared to those in the control group, and the CD3, CD4, and CD4/CD8 were significantly increased 7 and 14 days after surgery (=0.027 and < 0.001 versus =0.008 and < 0.001 versus =0.010 and < 0.001) and IgA, IgG, and IgM 3, 7, and 14 days after surgery in the study group ( < 0.001, < 0.001, and < 0.001 versus < 0.001, < 0.002, and < 0.001 versus < 0.001, < 0.001, and < 0.001). The complications such as abdominal, lung, wound, and urinary infection were also significantly decreased ( =0.017; < 0.001 and < 0.001 versus < 0.001 and < 0.001) and the protein (PA) 3, 7, and 14 days after surgery (=0.011, =0.002, and =0.022) in the study group compared to those in the control group. Cellular and humoral immunity indications in the study group are significantly higher than those before operation compared to those in the control group, and the CD3, CD4, and CD4/CD8 were significantly increased 7 and 14 days after surgery (=0.027 and < 0.001 versus =0.008 and < 0.001 versus =0.010 and < 0.001) and IgA, IgG, and IgM 3, 7, and 14 days after surgery in the study group ( < 0.001, < 0.001, and < 0.001 versus < 0.001, < 0.002, and < 0.001 versus < 0.001, < 0.001, and < 0.001). The complications such as abdominal, lung, wound, and urinary infection were also significantly decreased ( =0.017; =0.036; =0.041; =0.004).
CONCLUSIONS
Qihuang decoction combined with enteral nutrition can promote the absorption of enteral nutrition with improving the immune and reducing complications of infection.
目的
胃癌患者早期营养支持可改善其营养状况，但对免疫功能的影响尚未得到证实。本研究旨在分析芪黄汤联合肠内营养对胃癌术后营养及免疫功能的影响。
方法
从我院随机选取研究组120例胃癌术后患者和对照组117例患者作为研究对象。比较手术前及术后1、3、7和14天的营养、免疫指标及并发症发生率。
结果
研究组除血红蛋白（HB）外的营养指标均显著高于术前，术后7天和14天白蛋白（ALB）和前白蛋白（TP）显著升高（<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且<0.001且
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