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旱莲草综述:从药理化学多样性到产品技术开发。

Achyrocline satureioides review: From the pharmacochemical diversity to the technological development of products.

机构信息

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas, Porto Alegre, Rio Grande do Sul, Brazil.

Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Farmacociências, Porto Alegre, RS, Brazil.

出版信息

Fitoterapia. 2023 Jul;168:105537. doi: 10.1016/j.fitote.2023.105537. Epub 2023 May 22.

Abstract

Achyrocline satureioides (Lam.) DC (Asteraceae) is a native species of the southeastern subtropical and temperate region of South America, popularly known as "marcela" or "macela". This species is recognized, in traditional medicine, by diverse biological activities such as digestive, antispasmodic, anti-inflammatory, antiviral, sedative, hepatoprotective, among others. Some of these activities have been related to the presence of phenolic compounds, including flavonoids, phenolic acids, terpenoids in the essential oils, coumarins and phloroglucinol derivatives reported to the species. The approaches on the technological development of phytopharmaceutical products of this species provided relevant advances in the optimization of the extraction and product obtention, especially spray-dried powders, hydrogels, ointments, granules, films, nanoemulsions and nanocapsules. The most relevant biological activities described for the extracts or derivative products from A. satureioides were antioxidant, neuroprotective, antidiabetic, antiobesity, antimicrobial, anticancer effects, and obstructive sleep apnea syndrome. The scientific and technological findings reported for the species, in conjunction with its traditional use and cultivation, reveal the high potential of the species for diverse industrial applications.

摘要

Achyrocline satureioides(Lam.)DC(菊科)是南美洲东南部亚热带和温带地区的本地物种,俗称“marcela”或“macela”。该物种在传统医学中因其多种生物活性而被认可,如消化、抗痉挛、抗炎、抗病毒、镇静、保肝等。其中一些活性与酚类化合物的存在有关,包括黄酮类、酚酸类、挥发油中的萜类化合物、香豆素和苯并呋喃醇衍生物。对该物种植物药产品的技术开发方法为提取和产品获得的优化提供了相关进展,特别是喷雾干燥粉末、水凝胶、软膏、颗粒、薄膜、纳米乳液和纳米胶囊。描述的提取物或衍生产品的最相关生物活性是抗氧化、神经保护、抗糖尿病、抗肥胖、抗菌、抗癌作用和阻塞性睡眠呼吸暂停综合征。该物种的科学和技术研究结果,结合其传统用途和种植,揭示了该物种在多种工业应用中的巨大潜力。

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