Department of Gynaecology and Obstetrics, The General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang City, China.
BMC Pregnancy Childbirth. 2023 May 24;23(1):380. doi: 10.1186/s12884-023-05606-5.
As a leading cause of pregnancy and fetal mortality, pre-eclampsia impacts about 5-8% of pregnancies globally. To date, few studies have focused on the role played by (NOD)-like receptors protein 3 (NLRP3) in peripheral blood in early-onset pre-eclampsia (PE). In this study, we investigated whether NLRP3 expression in monocytes before 20 weeks of gestation was associated with an increased risk of early-onset PE.
During the study period from 2019 to 2021, women with singleton pregnancies were enrolled in this prospective study at the General Hospital of Northern Theater Command. A generalized additive model (GAM) and logistic regression models were applied to determine any association between NLRP3 and the risk of early-onset PE.
In total, 571 and 48 subjects were included in the control and pre-eclampsia groups, respectively. The GAM and logistic regression models showed that NLRP3 was a significant factor for PE occurrence. The area under the curve, accuracy, specificity, sensitivity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.86, 0.82, 0.95, 0.72, 15.17, 0.29, and 52.0, respectively.
The monitoring for NLRP3 in peripheral blood may be a potential, prospectively identifying risk factor for preeclampsia.
子痫前期是导致妊娠和胎儿死亡的主要原因之一，全球约有 5-8%的妊娠受到影响。迄今为止，很少有研究关注 NOD 样受体蛋白 3（NLRP3）在早发型子痫前期（PE）患者外周血中的作用。本研究旨在探讨妊娠 20 周前单核细胞中 NLRP3 的表达是否与早发型 PE 的发生风险增加有关。
本研究为前瞻性研究，纳入了 2019 年至 2021 年在北部战区总医院单胎妊娠的女性。应用广义加性模型（GAM）和逻辑回归模型来确定 NLRP3 与早发型 PE 风险之间的任何关联。
本研究共纳入了 571 例对照组和 48 例子痫前期组的受试者。GAM 和逻辑回归模型显示 NLRP3 是 PE 发生的一个显著因素。曲线下面积、准确性、特异性、敏感性、阳性似然比、阴性似然比和诊断优势比分别为 0.86、0.82、0.95、0.72、15.17、0.29 和 52.0。
外周血 NLRP3 的监测可能是子痫前期潜在的、前瞻性的识别危险因素。
