治疗前后重度抑郁发作中 38 种酰基肉碱的代谢组学特征。
Metabolomic profiles of 38 acylcarnitines in major depressive episodes before and after treatment.
机构信息
CESP, MOODS Team, INSERM UMR 1018, Faculté de Médecine, Univ Paris-Saclay, Le Kremlin Bicêtre, Paris, F-94275, France.
Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Hôpitaux Universitaires Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, Paris, F-94275, France.
出版信息
Psychol Med. 2024 Jan;54(2):289-298. doi: 10.1017/S003329172300140X. Epub 2023 May 25.
BACKGROUND
Major depression is associated with changes in plasma L-carnitine and acetyl-L-carnitine. But its association with acylcarnitines remains unclear. The aim of this study was to assess metabolomic profiles of 38 acylcarnitines in patients with major depression before and after treatment compared to healthy controls (HCs).
METHODS
Metabolomic profiles of 38 plasma short-, medium-, and long-chain acylcarnitines were performed by liquid chromatography-mass spectrometry in 893 HCs from the VARIETE cohort and 460 depressed patients from the METADAP cohort before and after 6 months of antidepressant treatment.
RESULTS
As compared to HCs, depressed patients had lower levels of medium- and long-chain acylcarnitines. After 6 months of treatment, increased levels of medium- and long-chain acyl-carnitines were observed that no longer differed from those of controls. Accordingly, several medium- and long-chain acylcarnitines were negatively correlated with depression severity.
CONCLUSIONS
These medium- and long-chain acylcarnitine dysregulations argue for mitochondrial dysfunction through fatty acid -oxidation impairment during major depression.
背景
重度抑郁症与血浆左旋肉碱和乙酰左旋肉碱的变化有关。但其与酰基肉碱的关系尚不清楚。本研究旨在评估与健康对照组（HCs）相比，重度抑郁症患者治疗前后 38 种酰基肉碱的代谢组学特征。
方法
在 VARIETE 队列的 893 名 HCs 和 METADAP 队列的 460 名抑郁患者中，通过液相色谱-质谱法对 38 种血浆短链、中链和长链酰基肉碱的代谢组学特征进行了分析。
结果
与 HCs 相比，抑郁患者的中链和长链酰基肉碱水平较低。经过 6 个月的治疗后，观察到中链和长链酰基肉碱水平升高，不再与对照组存在差异。因此，一些中链和长链酰基肉碱与抑郁严重程度呈负相关。
结论
这些中链和长链酰基肉碱的失调表明，在重度抑郁症期间，通过脂肪酸氧化损伤导致线粒体功能障碍。
Zotero 插件