Department of Chemistry, University of Delhi, Delhi 110007, India.
Chem Commun (Camb). 2023 Jun 8;59(47):7263-7266. doi: 10.1039/d3cc01586f.
A transition-metal-free and base-promoted one-pot synthesis of 2,3,4-trisubstituted 1--pyrroles has been developed. The reaction occurs through the [3+2] cycloaddition of differently functionalized ynones and isocyanides. The reaction's advantageous features are operational simplicity, atom economy, and functional group tolerance with broad substrate scope. In addition, 1,3-bis-pyrrole formation and gram-scale synthesis were also achieved. Furthermore, the synthetic utility of the products was also investigated isocyanide insertion and pyrrole-triazole hybrid formation in good yield.
发展了一种无过渡金属和碱促进的一锅法合成 2,3,4-三取代 1--吡咯的方法。该反应通过不同官能化的炔酮和异氰化物的[3+2]环加成反应进行。该反应具有操作简单、原子经济性和官能团耐受性的优点，底物范围广泛。此外，还实现了 1,3-双吡咯的形成和克级规模的合成。此外，还研究了产物的合成用途，异氰化物插入和吡咯-三唑杂合形成的收率良好。
