Applied Biomedical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
Curr Med Chem. 2024;31(24):3791-3797. doi: 10.2174/0929867330666230523155750.
Trimethylamine N-oxide (TMAO) is a metabolite of the gut microbiota that is considered a cardiovascular risk factor. Because bariatric surgery (BS) produces changes in the composition of the gut microbiota, the production of TMAO can be compromised. Thus, the purpose of this meta-analysis was to determine the effect of BS on circulating TMAO levels.
A systematic search was carried on in Embase, PubMed, Web of Science, and Scopus databases. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V2 software. The overall effect size was determined by a random-effects metaanalysis and the leave-one-out approach.
Random-effects meta-analysis of 5 studies consisting of 142 subjects demonstrated a significant increase in circulating TMAO levels after BS (SMD: 1.190, 95% CI: 0.521, 1.858, p<0.001; I:89.30%).
Considering that levels of TMAO are affected after BS due to gut microbial metabolism alteration, there has been a significant elevation in TMAO concentrations observed to occur after BS in obese subjects.
三甲胺 N-氧化物（TMAO）是肠道微生物群的一种代谢物，被认为是心血管风险因素。由于减重手术（BS）会改变肠道微生物群的组成，TMAO 的产生可能会受到影响。因此，本荟萃分析的目的是确定 BS 对循环 TMAO 水平的影响。
在 Embase、PubMed、Web of Science 和 Scopus 数据库中进行系统检索。使用 Comprehensive Meta-Analysis（CMA）V2 软件进行荟萃分析。总体效应大小通过随机效应荟萃分析和逐一剔除法确定。
对包括 142 名受试者的 5 项研究进行随机效应荟萃分析表明，BS 后循环 TMAO 水平显著升高（SMD：1.190，95%CI：0.521，1.858，p<0.001；I：89.30%）。
考虑到 BS 后肠道微生物代谢改变会影响 TMAO 水平，肥胖受试者 BS 后 TMAO 浓度显著升高。
