Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, PR China.
College of Grassland Science and Technology, China Agricultural University, Beijing 100193, PR China.
J Agric Food Chem. 2023 Jun 7;71(22):8458-8470. doi: 10.1021/acs.jafc.3c02441. Epub 2023 May 25.
Inflammatory bowel disease is known to be associated with alterations in gut microbiota. The bioactive compound syringic acid has been shown to alleviate inflammatory bowel disease, but its interaction with gut microbiota and mechanism of action remain unclear. To address this, we conducted a study in which we investigated the potential benefits of syringic acid in a mouse model of dextran sulfate sodium-induced colitis through gut microbiota modulation. Our results show that oral administration of syringic acid effectively reduced symptoms of colitis, as indicated by reduced disease activity index, and histopathology scores. Moreover, syringic acid administration enriched the abundance of and in mice, suggesting a restoration of impaired gut microbiota. Notably, we found that the effects of syringic acid were similar to those of fecal microbiota transplantation in dextran sulfate sodium-induced mice. Further analysis revealed that syringic acid inhibited the NLRP3-Cas-1-GSDMD-IL-1β inflammatory vesicle signaling pathway, leading to amelioration of colonic inflammation in a gut microbiota-dependent manner. Our findings demonstrate the potential of syringic acid as a preventive and therapeutic agent for inflammatory bowel disease.
炎症性肠病已知与肠道微生物群的改变有关。生物活性化合物丁香酸已被证明可以缓解炎症性肠病，但它与肠道微生物群的相互作用和作用机制仍不清楚。为了解决这个问题，我们通过调节肠道微生物群，在葡聚糖硫酸钠诱导的结肠炎小鼠模型中研究了丁香酸的潜在益处。我们的研究结果表明，口服丁香酸可有效减轻结肠炎症状，表现在疾病活动指数和组织病理学评分降低。此外，丁香酸的给药增加了 和 在小鼠中的丰度，表明受损肠道微生物群得到了恢复。值得注意的是，我们发现丁香酸的作用与葡聚糖硫酸钠诱导的小鼠粪便微生物群移植的作用相似。进一步的分析表明，丁香酸抑制 NLRP3-Cas-1-GSDMD-IL-1β 炎性囊泡信号通路，从而以依赖肠道微生物群的方式改善结肠炎症。我们的研究结果表明，丁香酸可能是一种预防和治疗炎症性肠病的潜在药物。
